🗂️

Archived grant — no longer open

This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.

grant

New mouse models to investigate host-microbe dynamics in physiology and innate immunity

Organization UNIVERSITY OF CALIFORNIA AT DAVISLocation DAVIS, UNITED STATESPosted 20 Nov 2023Deadline 31 Oct 2025 ⚠️
NIHUS FederalResearch GrantFY2025ASCVDAddressAnimalsAtherosclerosisAtherosclerotic Cardiovascular DiseaseAutomobile DrivingAutoregulationBiologic ModelsBiological ModelsBiologyBirthBody SystemBody TissuesCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessChromosome 8Clustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColon CancerColon CarcinomaCommunitiesComplexDataDefensinsDiabetes MellitusDisciplineDiscipline of NursingDiseaseDisorderEcologic SystemsEcological SystemsEcosystemEffector CellEnergy harvestingEnteralEntericEpithelial CellsEquilibriumFemaleFosteringFoundationsFutureGI microbiotaGastrointestinal microbiotaGenesGeneticGenetic ModelsGerm-FreeGestationHealthHealth PromotionHomeostasisHost FactorHost Factor ProteinHumanIndividualInfectionInflammationInjuryInnate ImmunityIntegration Host FactorsInterventionIntestinalIntestinesIntracellular Communication and SignalingKO miceKnock-outKnock-out MiceKnockoutKnockout MiceLaboratoriesLactationLengthLifeMammaliaMammalsMediatingMetabolic syndromeMiceMice MammalsMicrobeModel SystemModelingModern ManMolecularMucosaMucosal ImmunityMucosal TissueMucous MembraneMurineMusNamesNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNull MouseNulliparasNulliparityNulliparousNursingNursing FieldNursing ProfessionNutrientObesityOrgan SystemOrganism-Level ProcessOrganismal ProcessPaneth CellsParturitionPathogenesisPeptidesPhenotypePhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPhysiologyPlayPredispositionPregnancyPrimiparityProcessProductionProteinsReproducibilityReproductive BiologyResearchRoleSalutogenesisShapesSignal TransductionSignal Transduction SystemsSignalingSiteSmall IntestinesStimulusStudy modelsSubcellular ProcessSusceptibilitySymbiosisTimeTissuesTransmissionWeaningadiposityalpha-Defensinsanti-microbialanti-microbial peptideantimicrobialatheromatosisatherosclerotic diseaseatherosclerotic vascular diseasebalancebalance functionbeneficial florabeneficial microbesbeneficial microflorabeneficial microorganismbiological signal transductionbowelcancer in the coloncommensalismcommunity microbesconstitutive expressionconstitutive gene expressioncorpulencediabetesdietarydrivingdysbacteriosisdysbiosisdysbioticenteral infectionenteric infectionenteric microbial communityenteric microbiotaenteric pathogen infectionenteropathogen infectionenteropathogenic infectionexperimentexperimental researchexperimental studyexperimentsfitnessgastrointestinal microbial floragut communitygut floragut microbe communitygut microbial communitygut microbial compositiongut microbial consortiagut microbiotagut microbioticgut microflorahost microbe associationhost microbe relationshiphost microbiotahost microflorahost-microbe interactionshost-microbial interactionshost-microorganism interactionsimprovedin vivo Modelinfected with enteropathogeninjuriesinnovateinnovationinnovativeinsightintestinal floraintestinal infectionintestinal microbiotaintestinal microfloraintestinal tract microfloraintestine infectionlactatinglactationalmicrobe communitymicrobial communitymicrobial consortiamicrobial floramicrobial imbalancemicrobiotamicrobiota compositionmicrofloramicroorganism communitymouse modelmultispecies consortiamurine modelnamenamednamingnoveloffspringphysiologic modelpolymicrobial communityprimiparaprimiparouspromoting healthpupresident microbesresident microfloraresponsesmall bowelsmall moleculesocial roletooltransmission processuptakeα-Defensins♀

Applications closed.

Description preview

Recent studies support the hypothesis that the host plays an active role in maintaining homeostatic symbiosis
with the gut microbiota. However, the host-specific mechanisms employed to sculpt the microbiota remain to
be fully elucidated, in part, due to shortcomings of current in vivo models. Data from our group and others
support that…

🔒

Full details available on the Agency plan

Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.

Start 7-day free trial — $29.99/mo →

Agency Plan

7-day free trial

Unlock procurement & grants

Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.

$29.99 / month

  • 🔔Email alerts for new matching tenders
  • 🗂️Track tenders in your pipeline
  • 💰Filter by contract value
  • 📥Export results to CSV
  • 📌Save searches with one click
Start 7-day free trial →

Explore more

📍 More grants in UNITED STATES🏷 More NIH opportunities🏷 More US Federal opportunities🏷 More Research Grant opportunities🏢 All nih_reporter opportunities