grant
New and Disruptive Therapeutic Approaches to Target Fundamental Molecular Mechanisms Underlying Atrial Fibrillation
Organization UNIVERSITY OF CHICAGOLocation CHICAGO, UNITED STATESPosted 1 Feb 2022Deadline 31 Dec 2028
NIHUS FederalResearch GrantFY2025AblationAffectAgeAmericanAnimal ModelAnimal Models and Related StudiesApoplexyArrhythmiaAtrialAtrial FibrillationAuricular FibrillationAutonomic nervous systemBiological AgentBiological ProductsBrain Vascular AccidentCardiac ArrhythmiaCardiac AtriumCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeChronicClinicalCouplingDNA TherapyDevelopmentDiseaseDisorderElectroporationEpidemicFibrosisGene DeliveryGene Transfer ClinicalGenesGenetic InterventionGoalsHDAC6HDAC6 geneHeart ArrhythmiasHeart AtriumIncidenceInflammasomeIntracellular Communication and SignalingIon ChannelIonic ChannelsKIAA0901MediatingMembrane ChannelsMicro-tubuleMicrotubulesMolecularMuscle DiseaseMuscle DisordersMuscular DiseasesMyopathic ConditionsMyopathic Diseases and SyndromesMyopathic disease or syndromeMyopathyNervePatientsPhaseProteinsResearchRoleSignal TransductionSignal Transduction SystemsSignalingStrokeTherapeuticUniversitiesVenousWorkage associated diseaseage associated disorderage associated impairmentage dependent diseaseage dependent disorderage dependent impairmentage related human diseaseage-related diseaseage-related disorderage-related impairmentaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationatriumbiological signal transductionbiologicsbiopharmaceuticalbiotherapeutic agentbrain attackcardiac rhythmcerebral vascular accidentcerebrovascular accidentdevelopmentalelectroporative deliverygene electrotransfergene repair therapygene therapygene-based therapygene-based treatmentgene-directed therapygene-targeted therapygene-targeted treatmentgenetic therapygenomic therapyheart rhythmhistone deacetylase 6insightmodel of animalmuscular disordernoveloxidative damageoxidative injurypharmacologicpopulation agingpreventpreventingprotein homeostasisproteostasispublic health relevancesocial rolestrokedstrokessuccess
Description preview
PROJECT SUMMARY
Atrial fibrillation (AF) is the most common heart rhythm disorder that affects >3 million Americans and is a
major cause of stroke. Since AF is primarily an age-related disease, it is fast becoming an epidemic in a rapidly
aging population. Unfortunately, current therapeutic approaches to AF – both pharmacological and ablation-…
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