grant
Neutrophil regulation of brown adipose tissue homeostasis
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 15 Aug 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20251-Phosphatidylinositol 3-Kinase21+ years oldAblationAdipocytesAdipose CellAdoptive TransferAdrenalineAdultAdult HumanAdult-Onset Diabetes MellitusAgingAntibodiesAutoregulationB220BAT uncoupling proteinBacteriaBloodBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood Reticuloendothelial SystemBody TemperatureBody TissuesBrown Adipose TissueBrown FatCAGACD45CGLACardiovascular DiseasesCatecholaminesCell BodyCellsComplexDataDevelopmentElectron TransportEnergy ExpenditureEnergy MetabolismEpinephrineExhibitsExposure toFat CellsFatsFatty acid glycerol estersFeedbackFutureGP180Gene TranscriptionGenesGeneticGenetic TranscriptionGlycolysisGoalsHeat ProductionHibernating GlandHomeostasisHumanHypothermiaImmigrantImmuneImmunesImpairmentIn VitroInfantIntermediary MetabolismKO miceKetosis-Resistant Diabetes MellitusKineticsKnock-out MiceKnockout MiceLY5LeadLevarterenolLevonorepinephrineLipidsLipocytesMA387MRP8MacrophageMarrow NeutrophilMature LipocyteMature fat cellMaturity-Onset Diabetes MellitusMetabolicMetabolic DiseasesMetabolic DisorderMetabolic ProcessesMetabolismMiceMice MammalsMitochondriaMitochondrial ProteinsModern ManMurineMusMyelogenousMyeloidMyeloid CellsMφNIDDMNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeutrophil InfiltrationNeutrophil RecruitmentNeutrophilic GranulocyteNeutrophilic InfiltrateNeutrophilic LeukocyteNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNoradrenalineNorepinephrineNull MouseObesityOxidative PhosphorylationOxidative Phosphorylation PathwayPI-3 KinasePI3-KinasePI3CGPI3KGammaPI3kPIK3PIK3CGPIK3CG genePTPRCPTPRC genePathogenesisPathway interactionsPatientsPb elementPhagocytosisPhosphatidylinositol 3-KinasePhosphatidylinositol-3-OH KinasePhosphoinositide 3-HydroxykinasePhysiological HomeostasisPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationProcessProteinsPtdIns 3-KinaseRNA ExpressionRNA SeqRNA sequencingRNAseqRegulationRodentRodentiaRodents MammalsRoleS100A8S100A8 geneSlow-Onset Diabetes MellitusStable Diabetes MellitusSympathinsT2 DMT200T2DT2DMTemperatureTestingTherapeutic EpinephrineThermogenesisThesaurismosisTimeTissuesTranscriptionType 2 Diabetes MellitusType 2 diabetesType I Phosphatidylinositol KinaseType II Diabetes MellitusType II diabetesType III Phosphoinositide 3-KinaseWild Type Mouseadiposityadult onset diabetesadulthoodbrown adipose tissue uncoupling proteincardiovascular disordercell typecold stresscold temperatureconditional knock-outconditional knockoutcorpulencedevelopmentalelectron transferextracellularfat metabolismglucose metabolismheavy metal Pbheavy metal leadin vivointerestketosis resistant diabeteslipid metabolismlow temperaturematurity onset diabetesmembermetabolism disordermigrationmitochondrialnatural hypothermianeuronalneutrophilnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeutic targetnew therapy approachesnew therapy targetnew treatment approachnew treatment strategynovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeutic targetnovel therapy approachnovel therapy targetobese individualsobese patientsobese peopleobese personobese populationobese subjectspathwaypatients with obesitypreventpreventingrecruitresponsesocial rolethermogenintranscriptional reprogrammingtranscriptome sequencingtranscriptomic sequencingtype 2 DMtype II DMtype two diabetesuncoupling protein 1wildtype mouse
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PROJECT SUMMARY
Brown adipose tissue (BAT) is a thermogenic fat pad that is essential for maintaining core body temperature and
is associated with protection from numerous metabolic diseases. Adult patients with intact BAT activity are much
less likely to have obesity, type 2 diabetes, or cardiovascular disease (CVD), and obese individuals exhibit…
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