grant
Neutrophil-driven vascular inflammation in VCID and Mixed Alzheimer's Disease
Organization UNIVERSITY OF MIAMI CORAL GABLESLocation CORAL GABLES, UNITED STATESPosted 17 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAD pathologyAccelerationAcuteAdventitial CellAerobicAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's disease modelAlzheimer's disease pathologyAlzheimer's disease patientAlzheimer's disease riskAlzheimer's pathologyAlzheimer's patientAlzheimers DementiaAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAnatomic SitesAnatomic structuresAnatomyApoplexyArteriesArteriosclerotic DementiaAutomobile DrivingAβBBB permeabilizationBBB permeableBehaviorBiological MarkersBleedingBlood - brain barrier anatomyBlood NeutrophilBlood Polymorphonuclear NeutrophilBlood VesselsBlood capillariesBlood flowBlood leukocyteBlood-Brain BarrierBrainBrain Nervous SystemBrain TraumaBrain Vascular AccidentCancersCausalityCell BodyCell CommunicationCell Communication and SignalingCell InteractionCell SignalingCell Surface ProteinsCell-to-Cell InteractionCellsCerebral StrokeCerebrovascular ApoplexyCerebrovascular CirculationCerebrovascular StrokeCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationDegenerative Neurologic DisordersDiseaseDisease ProgressionDisorderDisturbance in cognitionDysfunctionEncephalonEtiologyFunctional disorderHemato-Encephalic BarrierHemorrhageHeterogeneityImmuneImmunesImpaired cognitionImpairmentInflammationInflammatoryInflammatory ResponseIntermediary MetabolismIntracellular Communication and SignalingInvestigationIschemic StrokeKnowledgeLeadLeukocytesLeukocytes Reticuloendothelial SystemLongitudinal StudiesMalignant NeoplasmsMalignant TumorMarrow NeutrophilMarrow leukocyteMediatingMediatorMetabolicMetabolic GlycosylationMetabolic ProcessesMetabolismMicrovascular DysfunctionModelingMolecularNerve CellsNerve CrushNerve DegenerationNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationNeuronsNeutrophil ActivationNeutrophilic GranulocyteNeutrophilic LeukocyteObstructionPathologyPatientsPatternPb elementPericapillary CellPericytesPerivascular CellPhysiologicPhysiologicalPhysiopathologyPolymorphonuclear CellPolymorphonuclear LeukocytesPolymorphonuclear NeutrophilsPopulationPrimary Senile Degenerative DementiaRNA SeqRNA sequencingRNAseqRegulationResearchRoleRouget CellsSignal TransductionSignal Transduction SystemsSignalingSingle cell seqStrokeTauopathiesTestingTimeTraumatic Brain InjuryVascular DementiaVascular DiseasesVascular DisorderWaste ProductsWhite Blood CellsWhite CellWorka beta peptideabetaaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging populationalzheimer modelalzheimer riskamyloid angiopathyamyloid betaamyloid pathologyamyloid-b proteinanaerobic glycolysisbeta amyloid fibrilbio-markersbiologic markerbiological signal transductionbiomarkerblood flow in brainblood lossblood vessel disorderblood-based biomarkerblood-based markerblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackbrain blood circulationbrain blood flowcapillarycardiac disease induced cognitive impairmentcardiovascular riskcardiovascular risk factorcausationcerebral blood flowcerebral circulationcerebral vascular accidentcerebrocirculationcerebrovascular accidentcerebrovascular blood flowcerebrovascular contribution to cognitive impairment and dementiacerebrovascular contributions to dementiachronic inflammatory diseasecognitive dysfunctioncognitive lossdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisease causationdisease modeldisorder modeldrivingendothelial dysfunctionglycosylationheavy metal Pbheavy metal leadhypoperfusionin vivo two-photon imaginglong-term studylongitudinal outcome studiesmalignancymicrovascular complicationsmicrovascular diseasemouse modelmurine modelneoplasm/cancerneural degenerationneural inflammationneuro-vascular unitneurodegenerationneurodegenerativeneurodegenerative illnessneuroinflammationneuroinflammatoryneurological degenerationneuron regenerationneuronalneuronal degenerationneuronal regenerationneuropathologic tauneuropathological tauneurovascular unitneutrophilpathophysiologypatient living with Alzheimer's diseasepatient suffering from Alzheimer's diseasepatient with Alzheimer'spatient with Alzheimer's diseasepopulation agingprimary degenerative dementiasenile dementia of the Alzheimer typesingle cell next generation sequencingsingle cell sequencingsmall vessel diseasesocial rolesoluble amyloid precursor proteinspecific biomarkersstrokedstrokestau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau proteinopathytau related neurodegenerationtau-induced pathologytauopathic neurodegenerative disordertauopathytherapeutic targettranscriptome sequencingtranscriptomic sequencingtraumatic brain damagevascularvascular amyloid accumulationvascular amyloid build upvascular amyloid depositionvascular amyloid depositsvascular amyloid pathologyvascular amyloidosisvascular cognitive impairment and dementiavascular contribution to impairment or dementiavascular contributions in dementiavascular contributions to cognition/dementiavascular contributions to cognitive decline and dementiavascular contributions to cognitive impairment and dementiavascular contributions to dementiavascular dysfunctionvascular inflammationvascular related dementiavasculopathywhite blood cellwhite blood corpuscle
Description preview
Summary: Substantial reductions in brain blood flow are found in patients with and mouse models of
neurodegenerative diseases, including Alzheimer’s Disease (AD). Vascular pathologies are prevalent in an aging
population and patients with AD. Despite their importance, vascular contributions to cognitive impairment and
dementia (VCID) and the…
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