grant
Neurotrophic strategy to mitigate chemotherapy-related brain injury
Organization UNIVERSITY OF CALIFORNIA-IRVINELocation IRVINE, UNITED STATESPosted 6 Sept 2023Deadline 31 Aug 2028
NIHUS FederalResearch GrantFY202514-Hydroxydaunomycin2-Amino-6-trifluoromethoxybenzothiazoleAcquired brain injuryAdriamycineAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureArchitectureBDNFBloodBlood PlasmaBlood Reticuloendothelial SystemBrainBrain InjuriesBrain Nervous SystemBrain-Derived Neurotrophic FactorBreast CancerBreast Cancer ModelBreast Cancer TreatmentBreast Cancer survivorBreast tumor modelCTXCYCLO-cellCancer PatientCancer SurvivorCancer TreatmentCarloxanCell Culture TechniquesChemotherapy ProtocolChemotherapy RegimenChemotherapy-Oncologic ProcedureChronicCiclofosfamidaCiclofosfamideCicloxalClafenClapheneClinicalClinical DataClinical ResearchClinical StudyCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive deficitsCognitive function abnormalCombination Chemotherapy RegimenCornu AmmonisCycloblastinCycloblastineCyclophosphamCyclophosphamideCyclophosphamidumCyclophosphanCyclophosphaneCyclophosphanumCyclostinCyclostineCytophosphanCytophosphaneCytoxanDataDendritesDiseaseDisorderDistressDisturbance in cognitionDoxorubicinDoxorubicinaDrug KineticsDrugsElectrophysiologyElectrophysiology (science)EncephalonEndoxanEndoxanaEnduxanEngineering / ArchitectureEnsureExposure toFosfaseronFutureGeneticGenoxalGenuxalGlutamatesHippocampusHumanHydroxyl DaunorubicinHydroxyldaunorubicinImpaired cognitionImpairmentL-GlutamateLedoxinaLinkLong-Term PotentiationMalignant Breast NeoplasmMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMeasurementMediatingMedicationMiceMice MammalsMitoxanModelingModern ManMurineMusNeosarNerve CellsNerve DegenerationNerve UnitNeural CellNeural Stem CellNeurobiologyNeurocyteNeuron DegenerationNeuronsNeurophysiology / ElectrophysiologyOralPathologicPatientsPerformancePharmaceutical PreparationsPharmacokineticsPhase I StudyPlasmaPlasma SerumPlayPre-Clinical ModelPreclinical ModelsPreclinical dataPrefrontal CortexProcytoxQOLQuality of lifeQuimioterapiaReticuloendothelial System, Serum, PlasmaRiluzoleRiskRodentRodent ModelRodentiaRodents MammalsRoleSafetySendoxanSeriesSeveritiesSliceSurvivorsSyklofosfamidSynapsesSynapticTestingTherapeuticToxic effectToxicitiesZytoxanamygdaloid nuclear complexanti-cancer therapyaxon growthaxonal growthbehavior measurementbehavioral measurebehavioral measurementbrain damagebrain-injuredcancer chemotherapycancer related cognitive declinecancer related cognitive dysfunctioncancer therapycancer-directed therapycancer-related cognitive impairmentcell culturecell cultureschemobrainchemotherapychemotherapy-induced cognitive impairmentchemotherapy-related cognitive impairmentcognitive defectscognitive dysfunctioncognitive functioncognitive losscognitive taskdrug/agentelectrophysiologicalenhancing factorglutamatergichigh riskhippocampalimprovedin vivomalignant breast tumormammary cancer modelmammary tumor modelmouse modelmurine modelnerve stem cellneural circuitneural circuitryneural degenerationneural inflammationneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurobiologicalneurocircuitryneurodegenerationneurodegenerativeneurogenesisneurogenic progenitorsneurogenic stem cellneuroinflammationneuroinflammatoryneurological degenerationneuron progenitorsneuronalneuronal degenerationneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitorneuroprotectionneuroprotectivepharmacologicphase 1 studypost-chemotherapy cognitive impairmentpre-clinicalpre-clinical studypreclinicalpreclinical findingspreclinical informationpreclinical studypreventpreventingprogenitor and neural stem cellsprogenitor cell maintenanceprogenitor cell proliferationprogenitor maintenanceprogenitor proliferationregenerative approachregenerative strategyregenerative techniquerepairrepairedresponseside effectsocial rolestem and progenitor cell proliferationstem cell maintenancestem cell proliferationsynapsesynaptic circuitsynaptic circuitry
Description preview
ABSTRACT
Cancer-related cognitive impairment (CRCI), often referred as “chemobrain”, is prevalent up to
75% of all breast cancer survivors. These impairments cause significant distress and reduce the
quality for life for survivors. Despite growing realization of the long-term clinical problem of CRCI
in millions of cancer survivors, there is a…
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