grant
Neurotoxicity in the adult rat following chronic exposure to methamphetamine
Organization NATIONAL INSTITUTE ON DRUG ABUSELocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanBehaviorBrainBrain Nervous SystemBrain regionChronicCirculatory CollapseCommon Rat StrainsCorpus StriatumCorpus striatum structureCrystal MethCrystal methamphetamineD1 receptorDeoxyephedrineDesoxyephedrineDifferences between sexesDiffers between sexesDopamine D1 ReceptorDorsalDoseEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFemaleGene ExpressionGene Expression AlterationGene TranscriptionGenesGenetic TranscriptionHDACHDAC ProteinsHistone DeacetylaseIndividualIntakeMETH useMesencephalonMessenger RNAMethamphetamineMethamphetamine use disorderMethylamphetamineMid-brainMidbrainMidbrain structureModelingN-MethylamphetamineNucleus AccumbensPatternPolyadenylationPrefrontal CortexProteinsRNA ExpressionRNA PolyadenylationRNA SeqRNA sequencingRNAseqRatRats MammalsRattusRelapseResistanceSelf AdministeredSelf AdministrationSex DifferencesSexual differencesShockStriate BodyStriatumSubstance Use DisorderTranscriptionTranscription Alterationaddictionaddictive disorderadulthoodbehavior phenotypebehavioral phenotypingcirculatory shockdiagnostic criteriaepigeneticallyexposure to methexposure to methamphetaminemRNAmalemethmeth exposuremeth use disordermeth usermethamphetamine exposuremethamphetamine usemethamphetamine userneuron toxicityneuronal toxicityneurotoxicitypsychostimulantresistantsexsex based differencessex-dependent differencessex-related differencessex-specific differencesshocksstriatalsubstance use and disordertranscriptome sequencingtranscriptomic sequencing♀♂
Description preview
We used a self-administration (SA) model and RNA sequencing revealed extensive transcriptional changes in the prefrontal cortex, nucleus accumbens, dorsal striatum, and midbrain of SR and SS rats. Notably, we identified shared genes with consistent expression patterns across all four brain regions—Fos and Ahsp in SR rats, and Tet1, Cym, and…
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