grant
Neuroprotective lipid mediators target penumbra in experimental ischemic stroke
Organization LSU HEALTH SCIENCES CENTERLocation NEW ORLEANS, UNITED STATESPosted 5 Jul 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY2025ATAC sequencingATAC-seqATACseqAnabolismAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryApoplexyAssay for Transposase-Accessible Chromatin using sequencingAstrocytesAstrocytusAstrogliaBBB permeabilizationBBB permeableBehaviorBehavioralBiologicalBleedingBlood - brain barrier anatomyBlood monocyteBlood-Brain BarrierBrainBrain EdemaBrain IschemiaBrain Nervous SystemBrain SwellingBrain VascularBrain Vascular AccidentCNS Nervous SystemCell BodyCell Communication and SignalingCell NucleusCell SignalingCell SurvivalCell ViabilityCellsCentral Nervous SystemCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCommon Rat StrainsDataDoseElderlyElectrophoresisElectrophoretic FractionationEncephalonEnzyme GeneEnzymesEventExtravasationFailureFatty AcidsFree Fatty AcidsFrequenciesGenderGene ClusterGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsHemato-Encephalic BarrierHemorrhageHistologicHistologicallyHortega cellHourInfarctionInflammationInflammatoryInflammatory ResponseIntervention StrategiesIntracellular Communication and SignalingIntracranial EdemaIschemiaIschemia-Reperfusion InjuryIschemic EncephalopathyIschemic PenumbraIschemic StrokeKnowledgeLeadLeakageLesionLong-term disabilityLow Molecular Weight Nuclear RNAMR ImagingMR TomographyMRIMRIsMacrophageMagnetic Resonance ImagingMarrow monocyteMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMembraneMicrogliaMiddle Cerebral Artery OcclusionModelingMolecularMφN-3 polyunsaturated fatty acidNMR ImagingNMR TomographyNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeuraxisNeurocyteNeurologic DisordersNeurological DisordersNeuronsNonesterified Fatty AcidsNuclear Magnetic Resonance ImagingNucleusOlder PopulationOmega-3 Fatty AcidsOmega-3 PUFAOmega-3 Polyunsaturated Fatty AcidOmega3Pathway interactionsPb elementPhasePhenotypePhosphatidesPhospholipidsProcessProtein AnalysisProteinsPublic HealthQOL improvementRNA ExpressionRandomizedRatRats MammalsRattusRecoveryReperfusion DamageReperfusion InjuryResearchRoleSignal TransductionSignal Transduction SystemsSignalingSmall Molecular Weight RNASmall Nuclear RNASpillageStrokeTechnologyTestingTherapeuticTimeTranscriptTranscriptionTranslatingUpregulationVery Long Chain Fatty AcidZeugmatographyadvanced ageadvanced age ratsagedaged rataged ratsassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingastrocytic gliabiologicbiological signal transductionbiosynthesisblood lossblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain attackcerebral vascularcerebral vascular accidentcerebro-vascularcerebrovascularcerebrovascular accidentdifferential expressiondifferentially expressedelderly ratsepigenomicsgeriatricgeriatric ratsgitter cellheavy metal Pbheavy metal leadimprovedimprovements in QOLimprovements in quality of lifeinfarctinflammatory modulationlipid mediatorlipidomicsmembrane structuremesogliamicroglial cellmicrogliocytemonocytemultiomicsmultiple omicsn-3 Fatty Acidsn-3 PUFAneural inflammationneuro-vascular unitneurobehavioralneurobehavioral testneuroinflammationneuroinflammatoryneurological diseaseneuronalneuroprotectionneuroprotectiveneurovascular unitnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapyold ratsolder groupsolder individualsolder personomega-3omega-3spanomicspathwayperivascular glial cellpreventpreventingquality of life improvementrandomisationrandomizationrandomly assignedrepairrepairedresponsesenior citizensingle cell genomicssnRNAsocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicsstroke modelstrokedstrokestherapeutically effectivetranscriptional differencesuRNAwet brain
Description preview
Abstract
Ischemic stroke is a leading cause of long-term disability in both genders and lacks effective therapeutic options.
We propose to study elovanoids (ELVs), which are stereospecific dihydroxylated derivatives of the free fatty
acids (FFAs) 32:6n-3 or 34:6n-3 that yield ELV-N32 and ELV-N34, respectively, to protect the stroke penumbra
from…
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