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Neuropeptide Y1 Receptor-Expressing Neurons in the Lateral Parabrachial Nucleus in Neuropathic Pain
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Sept 2023Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20252-PropanoneAcetoneAcute PainAcutely painfulAffectAffectiveAgonistAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAnalgesic AgentsAnalgesic DrugsAnalgesic PreparationAnalgesicsAnatomic SitesAnatomic structuresAnatomyAnimalsAnodynesAntinociceptive AgentsAntinociceptive DrugsBed Nucleus of Stria TerminalisBehaviorBehavioralBehavioral SymptomsBilateralBody TissuesBrainBrain Nervous SystemBrain StemBrain regionBrainstemCalciumCannulasCell NucleusChronicClozapineComplexConditioned Taste AversionCotton PlantCuesDataDevelopmentDimethyl formaldehydeDiseaseDisorderDrug TherapyEmotionalEncephalonFISH TechnicFISH TechniqueFISH analysisFISH assayFamilyFiberFluorescenceFluorescence In Situ HybridizationFluorescent in Situ HybridizationFormalinFutureGeneral PopulationGeneral PublicGeneticGlutamatesGossypiumHypersensitivityImplantIn SituIn Situ HybridizationInfusionInfusion proceduresInjuryInvestigatorsL-GlutamateLaboratoriesLateralLesionLightLong-term painMaintenanceMechanicsMentorsMesencephalic Central GrayMiceMice MammalsMidbrain Central GrayMolecularMotorMurineMusNPY-Y1 receptorNerve CellsNerve UnitNeural CellNeurocyteNeuronsNeuropathyNeuropeptide TyrosineNeuropeptide Y ReceptorNeuropeptidesNociceptionNociceptorsNucleusOpiatesOpioidOxidesPainPainfulPathologicPatientsPatternPeriaqueductal GrayPeripheralPeripheral nerve injuryPersistent painPharmacological TreatmentPharmacotherapyPhotometryPhotoradiationPonsPons CerebelliPons VaroliiPontinePontine structurePublicationsPublishingQOLQuality of lifeReceptor ProteinResearchResearch PersonnelResearchersRodent ModelRoleScientific PublicationSensorySliceSocietiesStimulusStria Terminalis NucleusStructureStructure of terminal stria nuclei of preoptic regionSurgical InjuriesSwabSystemTaste aversionTestingThalamic structureThalamusTherapeuticTissuesUnited StatesVeinsViralVirusWithdrawalWritingamygdaloid nuclear complexanatomical tracingannulus of the aqueductawakecareercell typechronic painchronic pain conditionchronic pain disorderchronic painful conditionconditioned place preferenceconstant paincottondevelopmentaldrug interventiondrug treatmentexcitatory neuronexperimentexperimental researchexperimental studyexperimentsglutamatergichealingheat stimulusin situ Hybridization Geneticsin situ Hybridization Staining Methodin vivoinfusionsinjuriesinsightlasting painmechanicmechanicalmidbrain central gray substancemouse modelmurine modelnerve injuryneural injuryneuronalneuropathicneuropathic painneuropeptide Yneuropeptide Y-Y1 receptorneuropeptide YY1 receptornociceptivenociceptive neuronson-going painongoing painpain killerpain medicationpain relieverpain signalpain-sensing neuronspain-sensing sensory neuronspain-sensing somatosensory neuronspainful neuropathypainkillerparabrachial nucleusperceptual stimulusperiaqueductal gray matterperipheral nerve crush injuriesperipheral nerve damagepharmaceutical interventionpharmacologicpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsphysicochemical phenomena related to the sensesplace conditioningpre-clinicalpreclinicalreceptorresponsesensory stimulusskillssocial rolesomatosensoryspared nervethalamiczona incerta
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Project Summary
Pain is a complex phenomenon that elicits somatosensory and motor reflexive responses together with marked
and long-lasting changes in emotional and autonomic states. While acute pain provides protection from tissue
damage, chronic or long-lasting pain, provides no protective function and is often incapacitating. Chronic pain…
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