grant
Neuronal Circuits Controlling Behavior: Genetic Analysis in Zebrafish
Organization EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTLocation UNITED STATES
NIHUS FederalResearch GrantFY202521+ years oldASDAblationAcousticsAdultAdult HumanAffectAlternate SplicingAlternative RNA SplicingAlternative SplicingAnterior Quadrigeminal BodyArchitectureArousalArrhythmiaAtrioventricular BlockAuditoryAutismAutistic DisorderBehaviorBehavior ControlBehavioralBehavioral ManipulationBehavioral MechanismsBiologic ModelsBiological ModelsBody TissuesBrachydanio rerioBradycardiaBrainBrain Nervous SystemBrain StemBrain imagingBrain regionBrainstemCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCa(v)1.2 channelCalciumCardiacCardiac ArrhythmiaCas nuclease technologyCausalityCav1.2 calcium channelCell BodyCell FunctionCell PhysiologyCell ProcessCellsCellular FunctionCellular PhysiologyCellular ProcessCerebellumChildhoodClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCollaborationsComplexComputer AnalysisCuesCytoplasmic GranulesDNA mutationDanio rerioDefectDetectionDevelopmentDevicesDiseaseDisorderDysfunctionEarly Infantile AutismEmbryoEmbryonicEncephalonEngineering / ArchitectureEnvironmentEtiologyExhibitsExonsExposure toFeverFishesFore-BrainForebrainFrequenciesFunctional disorderGene AlterationGene MutationGeneHomologGenesGenetic ChangeGenetic ModelsGenetic defectGenetic mutationGoalsHealthHeartHeart ArrhythmiasHeterozygoteHind BrainHomologHomologous GeneHomologueHumanHyperactivityImageImpairmentIndividualInfantile AutismIntellectual disabilityIntellectual functioning disabilityIntellectual limitationIsoformsKanner's SyndromeKnock-inL-type calcium channel alpha(1C)LabelLarvaLesionLibrariesLinkLocomotor ActivityMammaliaMammalsMapsMechanisms of Behavior and Behavior ChangeMediatingMesencephalonMethodsMiceMice MammalsMid-brainMidbrainMidbrain structureMissense MutationModel SystemModelingModern ManMolecularMorphologyMotor ActivityMurineMusMutationN-Methyl-D-Aspartate ReceptorsN-Methylaspartate ReceptorsNMDA Receptor-Ionophore ComplexNMDA ReceptorsNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocyteNeurodevelopmental DisorderNeurodevelopmental ImpairmentNeurologicNeurologicalNeurological Development DisorderNeuronsOligoOligonucleotidesOptic TectumOpticsOrganoidsOutputPathway interactionsPatientsPatternPhenotypePhotosensitizersPhotosensitizing AgentsPhysiologic pulsePhysiopathologyPlayPopulationPositionPositioning AttributePredispositionProsencephalonProtein IsoformsProteinsPulsePyrexiaRNA SplicingReceptor SignalingReporterReportingResolutionRhombencephalonScaffolding ProteinSchizophreniaSchizophrenic DisordersSeizuresSensorySingle Strand Break RepairSiteSplicingStartle ReactionStimulusStructureSubcellular ProcessSuperior ColliculusSusceptibilitySwimmingSynapsesSynapticSystemTachycardiaTechniquesTemperatureTestingTherapeuticTimothy syndromeTissuesTransgenic OrganismsTransmissionVariantVariationVisualVisualizationWater MovementsWorkZebra DanioZebra FishZebrafishadulthoodalpha(1C) channelalpha1C calcium channelapplied behavior analysisapplied behavioral analysisautism spectral disorderautism spectrum disorderautistic spectrum disorderbehavior mechanismbehavior studybehavioral controlbehavioral studybrain visualizationcausationcold temperaturecomputational analysescomputational analysiscomputer analysesdementia praecoxdevelopmentaldigitaldisease causationdisease modeldisorder modelexome sequencingexome-seqfebrilefebrisgene defectgene manipulationgenetic analysisgenetic manipulationgenetically manipulategenetically perturbgenome mutationgranuleheterozygosityhindbrainhuman diseaseimaginginhibitorinhibitory neuroninsightintellectual and developmental disabilityinterestknock-downknockdownknockinlimited intellectual functioninglow temperaturemalleable riskmissense single nucleotide polymorphismmissense single nucleotide variantmissense variantmodifiable riskmolecular biomarkermolecular markermorphometrymotor behaviormutantmutant alleleneuralneural circuitneural circuitryneurocircuitryneurodevelopmentneurodevelopmental diseaseneuronalneuronal circuitneuronal circuitryoligosopticaloptogeneticspathophysiologypathwaypediatricphotosensitizerpost-synaptic nervespost-synaptic neuronspostsynaptic nervespostsynaptic neuronsprepulse inhibitionpresynapticraphe nucleiresolutionsresponseschizophrenicscreeningscreeningssensory mechanismstartle responsesuperior colliculus Corpora quadrigeminasynapsesynaptic circuitsynaptic circuitrytherapeutic candidatetime intervaltooltranscriptomicstransgenictransmission processvisual tectumvoltagewater flow
Description preview
This project has three main goals.
1. Understanding central mechanisms that control sensory processing. In zebrafish, as in mammals, auditory startle responses are inhibited when an intense acoustic stimulus is preceded by a weak prepulse. This form of startle modulation, termed prepulse inhibition, is diminished in neurological conditions…
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