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Neuromodulatory regulation of cortical functional connectivity

Organization YALE UNIVERSITYLocation NEW HAVEN, UNITED STATESPosted 1 May 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAcetylcholineAddressAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAnatomic SitesAnatomic structuresAnatomyAnimalsAreaArousalAttentionBasal Nucleus of MeynertBehaviorBehavior monitoringBehavioralBrainBrain Nervous SystemCalciumCell Communication and SignalingCell SignalingCerebral cortexCognitionCognitiveColorComplexCoupledCouplingDataDegenerative Neurologic DisordersDiseaseDisorderElectrophysiologyElectrophysiology (science)EncephalonExhibitsGoalsImageIntracellular Communication and SignalingLevarterenolLevonorepinephrineLinkLocus CoeruleusMediatingMiceMice MammalsMonitorMotorMurineMusNeocortexNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuromodulatorNeuronsNeurophysiology / ElectrophysiologyNoradrenalineNorepinephrineNucleus Basalis of MeynertNucleus Pigmentosus PontisParalysis AgitansParkinsonParkinson DiseasePathologyPatternPerceptionPlayPrimary ParkinsonismPrimary Senile Degenerative DementiaProcessRegulationReporterResolutionRoleSensorySignal TransductionSignal Transduction SystemsSignalingSleepSystemTechniquesTestingVariantVariationWorkawakebasal forebrain cholinergic neuronsbehavioral monitoringbiological signal transductionblue nucleuscholinergiccognitive functiondegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdensityelectrophysiologicalexperimentexperimental researchexperimental studyexperimentshomotypical corteximagingimaging approachimaging based approachin vivoinnovateinnovationinnovativeinsightisocortexlocus ceruleus structureneocorticalneopalliumneuralneural controlneural regulationneurodegenerative illnessneuromodulationneuromodulatoryneuronalneuronal patterningneuroregulationnoradrenergicnovelnovel imaging techniquenucleus basalispharmacologicpreventpreventingprimary degenerative dementiaresolutionssenile dementia of the Alzheimer typesocial rolespatial and temporalspatial temporalspatiotemporaltherapeutic target

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Description preview

PROJECT SUMMARY:
Neuromodulatory signaling is thought to play key roles in regulating the activity of local and long-range circuits
in the brain and in mediating behavioral state-dependent changes in circuit function and cognition. Despite
extensive anatomical evidence, there is little functional data on neuromodulatory signaling across the cortex…

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