grant
Neuroimaging biomarkers for sense of control, catastrophic expectations, and stress reactivity as novel treatment targets for functional seizures.
Organization UNIVERSITY OF ALABAMA AT BIRMINGHAMLocation BIRMINGHAM, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAgeAmmon HornAmygdalaAmygdaloid BodyAmygdaloid NucleusAmygdaloid structureAreaArithmeticArousalAwardAwarenessBehaviorBrainBrain Nervous SystemBrain regionCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCaregiver well-beingCentral LobeClinicalClinical TrialsComplexCornu AmmonisDataDevelopmentDiagnosisDiseaseDisorderDysfunctionEmotionalEmotionsEncephalonEnrollmentEpilepsyEpileptic SeizuresEpilepticsEsthesiaEvaluationExpectancyExperimental DesignsExposure toFearFrightFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFutureGoalsGrantHealth Care SystemsHealth Care UtilizationHippocampusImageImpairmentIndividualInsulaInsula of ReilInterventionInvestigatorsIsland of ReilK-AwardsK-Series Research Career ProgramsKnowledge acquisitionMeasuresMental HealthMental HygieneMentorsNervous System DiseasesNervous System DisorderNeurologic DisordersNeurological DisordersOutcome MeasureParticipantPatient Self-ReportPatientsPerformancePersonsPhysiopathologyPopulationPrefrontal CortexPrevalencePsyche structurePsychological HealthReportingResearchResearch Career ProgramResearch PersonnelResearchersSeizure DisorderSeizuresSelf-ReportSensationStressSymptomsTechniquesTestingThinkingTrainingTreatment EfficacyWritingadulthoodagesamygdaloid nuclear complexassess effectivenessauditory feedbackcare giver well-beingcare giver wellbeingcareercareer developmentcaregiver wellbeingcingulate cortexco-morbidco-morbiditycognitive processcomorbiditycompare to controlcomparison controlconditioningcostdata acquisitiondata acquisitionsdetermine effectivenessdevelopmentaleffectiveness assessmenteffectiveness evaluationemotion regulationemotional regulationenrollepilepsiaepilepsy participantepilepsy patientepilepsy subjectepilepsy volunteerepileptic patientepileptic subjectepileptiformepileptogenicevaluate effectivenessexamine effectivenessexpectationfMRIhealth care service usehealth care service utilizationhippocampalimagingimprovedintervention efficacymeasurable outcomementalneuralneural imagingneuro-imagingneuroimagingneuroimaging biomarkerneuroimaging markerneurological diseaseneurological imagingnoveloutcome measurementpathophysiologypatients with epilepsyphysical symptomprogramspsychiatric co-morbiditypsychiatric comorbidityresponsesexskill acquisitionskill developmentsocialstemstress reactivitystress reductiontherapeutic efficacytherapy efficacythoughtstool
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Project Summary/Abstract
Functional seizures (FS) are a subtype of Functional Neurological Disorder (FND). FS are paroxysmal attacks
resembling epileptic seizures, but without corresponding epileptiform activity in the brain. They account for at
least 20% of new epilepsy evaluations and negatively affect independence, employability, and caregiver…
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