grant
Neurobiology and Brain Tumor Program (NBTP)
Organization ST. JUDE CHILDREN'S RESEARCH HOSPITALLocation MEMPHIS, UNITED STATESPosted 1 Apr 1997Deadline 31 Mar 2031
NIHUS FederalResearch GrantFY20260-11 years oldAccelerationAddressAdverse Late EffectsAreaAutomobile DrivingBasal Transcription FactorBasal transcription factor genesBasic ResearchBasic ScienceBiologyBrainBrain NeoplasiaBrain NeoplasmsBrain Nervous SystemBrain TumorsCAR T cell therapyCAR T cellsCAR T therapyCAR modified T cellsCAR-TCAR-TsCCSGCNS Embryonal TumorCancer CauseCancer Center Support GrantCancer EtiologyCancersCatchment AreaCell BodyCellsCentral Nervous System Embryonal NeoplasmCentral Nervous System Embryonal TumorChildChild YouthChildhood Brain NeoplasmChildhood Brain TumorChildhood CNS NeoplasmChildhood CNS TumorChildhood CancersChildhood Central Nervous System NeoplasmChildhood Central Nervous System TumorChildhood GliomaChildren (0-21)ClassificationClinicClinicalClinical ResearchClinical StudyClinical TrialsCognitiveCollaborationsCommunicationCommunitiesComprehensive Cancer CenterDependenceDevelopmentDiagnosticDiseaseDisease stratificationDisorderDoctor of PhilosophyEarly DiagnosisEducation and TrainingEducational ActivitiesEmbryonal Neoplasm of the CNSEncephalonEpendymomaFamilyFeedbackFinancial HardshipFundingGeneral Transcription Factor GeneGeneral Transcription FactorsGenomicsGlial Cell TumorsGlial NeoplasmGlial TumorGliomaGoalsGraduate EducationGuidelinesH3 K27M mutantH3 K27M mutationH3K27M mutantH3K27M mutationHistopathologyImmune mediated therapyImmunologically Directed TherapyImmunotherapyInfantInterdisciplinary ResearchInterdisciplinary StudyInterventionInvestigatorsJournalsKnowledgeLate EffectsLeadLeadershipLong-Term EffectsMagazineMalignant Childhood NeoplasmMalignant Childhood TumorMalignant NeoplasmsMalignant Pediatric NeoplasmMalignant Pediatric TumorMalignant TumorMalignant childhood cancerManuscriptsMedulloblastomaMethylationModelingModificationMolecularMorbidityMultidisciplinary CollaborationMultidisciplinary ResearchNational Institutes of HealthNeurobiologyNeurocognitiveNeuroglial NeoplasmNeuroglial TumorOncogenesisOncogenicOutcomePathogenesisPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPb elementPediatric GliomaPediatric high-grade gliomaPeer ReviewPh.D.PhDPhotonsPhysical condensationPineal Gland PNETPineal PNETPineal Primitive Neuroectodermal NeoplasmPineal Primitive Neuroectodermal TumorPrecision therapeuticsPreclinical TestingPredisposition genePrimitive Neuroectodermal Neoplasm of the Pineal GlandPrimitive Neuroectodermal Tumor of the Pineal GlandPublicationsPublishingQOL improvementRadiationRecurrent diseaseRelapsed DiseaseResearchResearch PersonnelResearchersResource SharingSaint JudeSaint Jude Children's Cancer CenterSaint Jude Children's Research HospitalScientific PublicationSeminalSeriesSourceSt. JudeSt. Jude Children's Cancer CenterSt. Jude Children's Research HospitalSt. Jude Children's Research Hospital Comprehensive Cancer CenterSt.Jude Children's Cancer CenterSt.Jude Children's Research HospitalSt.Jude Children's Research Hospital Comprehensive Cancer CenterStrategic PlanningStratificationStructureSubgroupSurvivorsSusceptibility GeneSystematicsT cells for CARTechnologyTestingToxic effectToxicitiesTrainingTraining and EducationTranscription Factor Proto-OncogeneTranscription factor genesTranslatingTranslational ResearchTranslational ScienceTranslationsUnited States National Institutes of HealthWHO Grade II Ependymal NeoplasmWHO Grade II Ependymal TumorWorld Health Organizationcancer death in childrencancer in a childcancer in childrencancer microenvironmentcancer mortality in childrencancer predispositioncancer related death in childrencareerchemotherapychild with cancerchildhood cancer deathchildhood cancer mortalitychildhood malignancychimeric antigen T cell receptorchimeric antigen receptor (CAR) T cell therapychimeric antigen receptor (CAR) T cellschimeric antigen receptor Tchimeric antigen receptor T cell therapychimeric antigen receptor T cellschimeric antigen receptor T therapychimeric antigen receptor fusion protein T-cellschimeric antigen receptor modified T cellsclinical practiceclinical trial enrollmentclinically actionablecommunity advisory boardcommunity advisory committeecommunity advisory panelcondensationcurative interventioncurative therapeuticcurative therapycurative treatmentsdata visualizationdeep learningdeep learning methoddeep learning strategydesigndesigningdevelopmentaldiffuse midline gliomadisease subgroupsdisease subtypedisorder subtypedrivingearly detectioneconomic hardshipeconomic strainfinancial adversityfinancial burdenfinancial distressfinancial insecurityfinancial instabilityfinancial strainfinancial stressfinancial worryfundamental researchglial-derived tumorheavy metal Pbheavy metal leadimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapiesimmune-based treatmentsimmuno therapyimprovedimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativekidsliquid biopsymalignancymeetingmeetingsmemberneoplasm/cancerneurobiologicalneuroglia neoplasmneuroglia tumornoveloutreachpatient oriented outcomespediatric CNS neoplasmpediatric CNS tumorpediatric brain neoplasmpediatric brain tumorpediatric cancerpediatric central nervous system neoplasmpediatric central nervous system tumorpediatric malignancypineoblastomapost-doctoral trainingpre-clinicalpre-clinical testingprecision therapiesprecision treatmentpreclinicalpredisposing geneprogramsprospectiveproton therapyquality of life improvementrisk stratificationside effectstandard of carestratify risksuccesssusceptibility allelesusceptibility locussusceptibility varianttherapeutic agent developmenttherapeutic developmenttooltranscription factortranslationtranslation researchtranslational investigationtrial designtumortumor microenvironmenttumorigenesistumors in the brainundergradundergraduateundergraduate studentyoungster
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PROJECT SUMMARY/ABSTRACT – NEUROBIOLOGY AND BRAIN TUMOR PROGRAM
Brain tumors are the leading cause of cancer-related death in children. Despite rapid advances in understanding disease biology, treatment approaches are still lacking for some patients and lead to long-term, debilitating side effects in others. The goal of the Neurobiology and Brain…
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