grant
Neurobehavioral consequences of Mild Traumatic Brain Injury and addiction risk: a cotwin-control study
Organization WASHINGTON UNIVERSITYLocation SAINT LOUIS, UNITED STATESPosted 30 Sept 2023Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY202512-20 years oldAcquired brain injuryActive Follow-upAddictive BehaviorAdolescenceAdolescentAdolescent YouthAgeAnxietyBehaviorBehavioralBrainBrain InjuriesBrain Nervous SystemCase-Base StudiesCase-Comparison StudiesCase-Compeer StudiesCase-Referent StudiesCase-Referrent StudiesCase/Control StudiesCausalityChildhoodCognitionCognitive DiscriminationCorpus CallosumCorpus CallosumsCorrelative StudyCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDWI (diffusion weighted imaging)DWI-MRIData AnalysesData AnalysisDevelopmentDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDiscriminationDisease Frequency SurveysEEGElectroencephalogramElectroencephalographyElectrophysiologyElectrophysiology (science)EncephalonEquationEtiologyEventFemaleFunctional MRIFunctional Magnetic Resonance ImagingFunctional impairmentGoalsHeritabilityHeterogeneityHigh PrevalenceHistoryIQ DeficitIdentical TwinsImpulsivityKnowledgeLinkMR ImagingMR TomographyMRIMRIsMTBIMagnetic Resonance ImagingMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical RehabilitationMental HealthMental HygieneMental disordersMental health disordersMethodologyMethodsModalityModelingMonozygotic twinsNMR ImagingNMR TomographyNerve CellsNerve UnitNeural CellNeural DevelopmentNeurocognitive DeficitNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingPathway interactionsPerformancePreventionPsychiatric DiseasePsychiatric DisorderPsychological HealthPsychopathologyPublic HealthRecording of previous eventsRehabilitationRehabilitation therapyReportingResolutionRestRiskRisk FactorsRoleSelf MedicationStructureSubstance Use DisorderSubstance abuse problemSymptomsTechniquesTestingThickThicknessTraumaTwin Multiple BirthTwinsYouthYouth 10-21Zeugmatographyabnormal psychologyabuse of substancesactive followupaddictionaddictive disorderadolescence (12-20)adverse consequenceadverse outcomeagesbrain controlbrain damagebrain-injuredcase controlcase-controlledcase-controlled studiescausationco-morbidco-morbiditycognitive functioncomorbiditycopingdMRIdata interpretationdesigndesigningdevelopmentaldiffusion tensor imagingdisease causationearly adolescenceearly initiation substance useearly onset substance useelectrophysiologicalemotion regulationemotional regulationfMRIfollow upfollow up assessmentfollow-upfollowed upfollowupfollowup assessmentgray matterhigh riskhistoriesindividual heterogeneityindividual variabilityindividual variationinnovateinnovationinnovativeinsightintelligence quotient deficitjuvenilejuvenile humanlong-term sequelaemental illnessmild TBImild brain traumamild traumatic brain injurymulti-modal neuro-imagingmulti-modalitymultimodal neuroimagingmultimodalitynegative affectnegative affectivityneuralneural imagingneuro-imagingneurobehavioralneurocognitive declineneurocognitive impairmentneurodevelopmentneuroimagingneurological imagingneuronalneurophysiologicalneurophysiologyneuropsychologicnovelpathwaypediatricphysical conditioningphysical healthprevent substance abuseprevent substance useprospectivepsychiatric illnesspsychological disorderrehab therapyrehabilitativerehabilitative therapyresolutionsrisk sharingsocial rolestress reactivitysubstance abusesubstance abuse controlsubstance abuse preventionsubstance usesubstance use and disordersubstance use preventionsubstance usingsubstantia albasubstantia griseatemporal measurementtemporal resolutiontime measurementtoolwhite matteryouth age♀
Description preview
Project Summary/Abstract
The overall goal of the proposed study is to identify long-term neurobehavioral consequences of childhood mild
traumatic brain injury (mTBI) for the developing brain and examine their contribution to addiction risk using a
rigorous cotwin-control design, longitudinal follow-up, and multimodal and innovative neuroimaging…
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