grant
Neural Mechanisms underlying the benefits of Aerobic Exercise in Advanced Parkinson's disease
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 15 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025Abnormal MovementsActive Follow-upAddressAerobic ActivityAerobic ExerciseAerobic TrainingAerobic fitnessAffectAnimalsAreaBasal GangliaBasal NucleiBlindedBrainBrain Nervous SystemCaringCerebral cortexClassificationClinicalClinical Practice GuidelineCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalControl GroupsDataDeep Brain StimulationDevicesDisturbance in cognitionDrugsDysfunctionDyskinesiasDyskinetic syndromeEEGElectroencephalogramElectroencephalographyEncephalonEnrollmentExerciseExhibitsFrequenciesFunctional disorderFutureGangliaGuidelinesHumanImpaired cognitionImpairmentInterventionLaboratoriesLiteratureLong-Term EffectsMDS-UPDRSMDS-Unified Parkinson's Disease Rating ScaleMedical RehabilitationMedicationMeta-AnalysisModern ManMotorMovement Disorder Society Unified Parkinson's Disease Rating ScaleNervous System DiseasesNervous System DisorderNeural GanglionNeurologic DisordersNeurological DisordersNucleus SubthalamicusOutcomeParalysis AgitansParkinsonParkinson DiseaseParkinsonianParkinsonian ConditionParkinsonian DiseasesParkinsonian DisordersParkinsonian SyndromeParkinsonismPatternPerformancePersonsPharmaceutical PreparationsPhysiopathologyPopulationPrimary ParkinsonismRandomizedRehabilitationRehabilitation therapyRestSeminalStructureStructure of subthalamic nucleusSubthalamic NucleusSymptomsSystemSystematicsTask PerformancesTechnologyTestingThalamic structureThalamusTherapeutic InterventionTimeTranslatingUPDRSUnified Parkinson's Disease Rating ScaleVulnerable PopulationsWithholding Treatmentactive followupattenuationcessation of treatmentclinical practice and guidelinescognitive dysfunctioncognitive losscognitive performancedrug/agentenrollexecutive controlexecutive functionexercise interventionexperiencefollow upfollow-upfollowed upfollowupimprove symptomimprovedinsightintervention therapymotor controlmotor diseasemotor disordermotor dysfunctionmotor symptomneuralneural mechanismneural networkneural patterningneurological diseaseneuromechanismpathophysiologyphysical activity interventionprimary outcomerandomisationrandomizationrandomly assignedrehab therapyrehabilitativerehabilitative therapysimulationsymptom improvementsymptomatic improvementthalamictreatment cessationvulnerable groupvulnerable individualvulnerable people
Description preview
PROJECT SUMMARY/ABSTRACT
A substantial body of evidence supports the concept that high intensity aerobic exercise improves Parkinson’s
disease (PD) symptomology in mild to moderate people with PD (PwPD). Despite advances in appreciating the
benefits of exercise as an adjunct to treating PD, there is an absence of data regarding how, or if,…
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