grant
Neural mechanisms of social attachment disruption in frontotemporal dementia
Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 1 Jun 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY202521+ years oldAdultAdult HumanAffectAgeAgingAmentiaAnimal ModelAnimal Models and Related StudiesBehaviorBehavior Conditioning TherapyBehavior ModificationBehavior TherapyBehavior TreatmentBehavioralBehavioral Conditioning TherapyBehavioral ModificationBehavioral TherapyBehavioral TreatmentBioinformaticsBiologic ModelsBiological ModelsBiology of AgingBody TissuesBrainBrain Nervous SystemBrain regionCaliforniaCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCell Communication and SignalingCell SignalingCellsCharacteristicsClinicalConditioning TherapyDegenerative Neurologic DisordersDementiaDiagnosticDiseaseDisorderDoctor of PhilosophyEmpathyEncephalonEndocrineExhibitsExpression SignatureFTD dementiaFiberFoundationsFrontal Temporal DementiaFrontotemporal DementiaFundingGene AlterationGene ExpressionGene Expression ProfileGene MutationGenesGeneticGoalsImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpairmentIn vivo two-photon calcium imagingIncidenceInterventionIntracellular Communication and SignalingInvestigatorsK-AwardsK-Series Research Career ProgramsKnock-outKnockoutLeadLinkMaintenanceMapsMediatingMediatorMentorsMentorshipMethodsMicrotusModel SystemMolecularMolecular AnalysisMolecular FingerprintingMolecular GeneticsMolecular ProfilingMonitorMotivationNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurobiologyNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeuroendocrineNeuroendocrine SystemNeurologic Degenerative ConditionsNeuronsNeurosciencesNeurosecretory SystemsNucleus AccumbensOcytocinOxytocinOxytocin ReceptorPC cell-derived growth factorPCDGFPGRN genePGRN proteinPair BondPathologyPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatternPb elementPh.D.PhDPhotometryPhysiciansPhysiologyPopulationPositionPositioning AttributeProgram DevelopmentProgranulinPsychiatristRNA SeqRNA sequencingRNAseqReceptor SignalingRecombinant OxytocinResearchResearch Career ProgramResearch MethodologyResearch MethodsResearch PersonnelResearchersRisk-associated variantRodentRodentiaRodents MammalsRoleSan FranciscoScientistSignal TransductionSignal Transduction SystemsSignalingSingle-Nucleus SequencingSocial BehaviorSocial isolationSymptomsSystemTestingTissuesTrainingUniversitiesViralVoleWorkadulthoodage associatedage associated alterationsage associated changesage associated diseaseage associated disorderage associated impairmentage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage dependent diseaseage dependent disorderage dependent impairmentage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related human diseaseage specificage specific alterationsage specific changesage-related diseaseage-related disorderage-related impairmentagedagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agebehavior changebehavior interventionbehavioral interventionbiological signal transductionbrain healthburden of diseaseburden of illnesscareercareer developmentcell typechanges with agecomparative genomicsdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia riskdesigndesigningdisease burdendisease modeldisorder modeleffective therapyeffective treatmentexperiencefield mousefront temporal dementiafrontal lobe dementiafrontotemporal lobar degeneration dementiafrontotemporal lobar dementiafrontotemporal lobe degeneration associated with dementiagene conservationgene defectgene expression patterngene expression signaturegene signaturesgenetic signaturegranulin precursorheavy metal Pbheavy metal leadimagingin vivo calcium imaginginnovateinnovationinnovativeinterestlate in lifelate lifelearning activitylearning methodlearning strategieslearning strategymodel of animalmodel organismmolecular profilemolecular signaturemutantmutant alleleneuralneural circuitneural circuitryneural mechanismneural patterningneurobiologicalneurocircuitryneurodegenerative illnessneuromechanismneuronalneuropathologicneuropathologicalneuropathologyneurophysiologicalneurophysiologyneuropsychiatricneuropsychiatric diseaseneuropsychiatric disorderneuropsychiatrynew approachesnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel approachesnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel strategiesnovel strategynovel therapeutic targetnovel therapy targetpathwaypatient oriented outcomesprairie voleprogramsprogranulin geneprogranulin proteinresearch and methodsrisk allelerisk factor for dementiarisk for dementiarisk generisk genotyperisk locirisk locusrisk variantsNuc-Seqsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqskillssnRNA sequencingsnRNA-seqsocialsocial attachmentsocial bondingsocial cognitionsocial defectssocial deficitssocial disorderssocial dysfunctionsocial rolesocial vulnerabilitysociobehaviorsociobehavioralsynaptic circuitsynaptic circuitrytherapeutic targettooltranscriptional profiletranscriptional signaturetranscriptome profilingtranscriptome sequencingtranscriptomic profilingtranscriptomic sequencingtranscriptomics
Description preview
PROJECT SUMMARY/ABSTRACT
Social cognition, and social attachment in particular, is often significantly disrupted in age-related
neuropsychiatric disease. Frontotemporal dementia (FTD) is characterized by disruptions in social attachment
behavior and loss of empathy early in the course of the disease. We currently lack a mechanistic understanding…
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