grant
Neural mechanisms of gait disturbances as individualized digital biomarker trajectories in preclinical dementia
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 24 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAD dementiaAD pathologyAD related dementiaADRDAbnormal gaitActivities of Daily LivingActivities of everyday lifeAgingAlzheimer Type DementiaAlzheimer beta-ProteinAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's Amyloid beta-ProteinAlzheimer's DiseaseAlzheimer's amyloidAlzheimer's and related dementiasAlzheimer's biomarkerAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease biological markerAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease pathologyAlzheimer's disease related dementiaAlzheimer's disease riskAlzheimer's pathologyAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmyloidAmyloid Alzheimer's Dementia Amyloid ProteinAmyloid Beta-PeptideAmyloid Protein A4Amyloid SubstanceAmyloid beta-ProteinAmyloid βAmyloid β-PeptideAmyloid β-ProteinAndroid AppAndroid ApplicationAssessment instrumentAssessment toolAβBiological MarkersBrainBrain Nervous SystemBrain imagingBrain regionCalibrationCausalityCell Communication and SignalingCell Phone ApplicationCell SignalingCell phone AppCellular Phone AppCellular Phone ApplicationClassificationClinicClinicalCognitionCognition DisordersCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComputer Vision SystemsCost MeasuresCost metricsCouplingDWI (diffusion weighted imaging)DWI-MRIDataData CollectionDegenerative DisorderDegenerative Neurologic DisordersDementiaDependenceDeteriorationDiagnosisDiagnostic FindingsDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDigital biomarkerDiseaseDisease ProgressionDisorderDisturbance in cognitionDysfunctionEducationEducational BackgroundEducational aspectsEncephalonEquilibriumEtiologyEvaluationFunctional disorderGaitGait abnormalityGait disorderGait disturbancesGait dysfunctionGait impairmentGait speedHandHomeHumanImpaired cognitionIncidenceIndividualIntracellular Communication and SignalingJointsLanguageLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemory DeficitMemory impairmentModern ManMonitorMotionMotorMovementMultivariate AnalysesMultivariate AnalysisNMR ImagingNMR TomographyNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeurologistNeuropsychologiesNeuropsychologyNuclear Magnetic Resonance ImagingParalysis AgitansParkinsonParkinson DiseaseParticipantPathologyPatternPhenotypePhysical PerformancePhysiopathologyPopulationPositionPositioning AttributePrimary ParkinsonismPrimary Senile Degenerative DementiaResearchRestScanningScreening procedureSensitivity and SpecificitySignal TransductionSignal Transduction SystemsSignalingSigns and SymptomsSkeletonSmart Phone AppSmart Phone ApplicationSmartphone AppSpecific qualifier valueSpecificitySpecifiedSystemSystematicsTestingTimeVideo RecordingVideorecordingWalking impairmentWorkZeugmatographya beta peptideabetaage associatedage associated neurodegenerationage associated neurodegenerative diseaseage associated neurodegenerative disorderage correlatedage dependentage dependent neurodegenerationage dependent neurodegenerative conditionage dependent neurodegenerative diseaseage dependent neurodegenerative disorderage linkedage relatedage related neurodegenerationage specificage-driven neurodegenerative disordersage-related neurodegenerative diseaseage-related neurodegenerative disorderaging associated neurodegenerationaging associated neurodegenerative diseaseaging related neurodegenerationaging related neurodegenerative diseaseaging related neurodegenerative disorderalzheimer riskamyloid betaamyloid-b proteinapp on a smartphoneapplication on a smartphonebalancebalance functionbeta amyloid fibrilbio-markersbiologic markerbiological signal transductionbiomarkerbiomarker identificationbody movementbrain visualizationcausationcell phone based appclinical phenotypecognitive diseasecognitive disordercognitive dysfunctioncognitive losscognitive syndromecomputer visionconnectomeconsumption measurescostcost measurementdMRIdaily living functiondaily living functionalitydegenerative conditiondegenerative diseasedegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdesigndesigningdiagnostic approachdiagnostic strategydiffusion tensor imagingdigitaldigital markerdisease causationdisease phenotypefunctional abilityfunctional capacityhandshomesiOS appiOS applicationiPhone AppiPhone Applicationidentification of biomarkersidentification of new biomarkersinstrumentmarker identificationmemory dysfunctionmild cognitive disordermild cognitive impairmentmobile phone appmotor diseasemotor disordermotor dysfunctionmulti-modalitymultimodalityneuralneural imagingneural mechanismneuro-imagingneurodegenerative illnessneuroimagingneuroimaging biomarkerneuroimaging markerneurological imagingneuromechanismneuropsychologicp-taup-τpathophysiologyphenotypic biomarkerphenotypic markerphone appphone applicationphospho-tauphospho-τphosphorylated taupost-translational modification of tauposttranslational modification of taupre-clinicalpreclinicalprimary degenerative dementiascreeningscreening toolsscreeningssenile dementia of the Alzheimer typeskeletonssmartphone applicationsmartphone based appsmartphone based applicationsoluble amyloid precursor proteintau phosphorylationtau posttranslational modificationtau-1three dimensionaltoolvideo recording systemτ phosphorylation
Description preview
PROJECT SUMMARY
Alzheimer's disease and related dementias (AD/ADRD) rank prominently among age-associated
neurodegenerative disorders, with Parkinson’s disease trailing as the second most common. Contemporary
studies on AD and Mild Cognitive Impairment (MCI) have unveiled cognitive decline indicators mirrored in
nuances within gait and hand…
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