grant
Neural circuits regulating brain-wide effects of oxytocin neurons
Organization NEW YORK UNIVERSITY SCHOOL OF MEDICINELocation NEW YORK, UNITED STATESPosted 15 Sept 2018Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AcetylcholineAddressAffectAmmon HornAnatomic SitesAnatomic structuresAnatomyAnimalsAnxietyAreaArousalAutoregulationBehaviorBehavioralBlood PressureBlood VesselsBrainBrain Nervous SystemBrain regionBusiness-Friendly AtmosphereCNS Nervous SystemCardiacCardiac ChronotropismCaringCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCentral Nervous SystemChild RearingClassificationCollaborationsCommunicationComputer ModelsComputerized ModelsCornu AmmonisCouplingDataData Science CoreData Science Resource CoreDedicationsDifferential Gene ExpressionDiscipline of NursingDorsalElectrophysiologyElectrophysiology (science)EncephalonEndocrine systemEndocrine/Metabolic Organ SystemEnsureFast-Wave SleepFeedbackFire - disastersFiresGoalsHeart RateHippocampusHomeostasisHormonal SystemHydrogen OxideHypothalamic HormonesHypothalamic structureHypothalamusImageIn VitroIndividualIntracellular Communication and SignalingKidneyKidney Urinary SystemKnowledgeLaboratoriesLactationLiteratureLocomotionMammaliaMammalsMeasuresMemoryMetabolic/Endocrine Body SystemMethodsMiceMice MammalsMolecularMothersMurineMusNREMNeocortexNerve CellsNerve UnitNeural CellNeural TransmissionNeuraxisNeurocyteNeurohypophysisNeuromodulatorNeuronsNeurophysiology / ElectrophysiologyNucleusNursingNursing FieldNursing ProfessionOcytocinOrganOrganism-Level ProcessOrganismal ProcessOutputOxytocinParadoxical SleepParaventricular Hypothalamic NucleusParentingParenting behaviorPathologicPathway interactionsPatternPhysiologicPhysiologic ProcessesPhysiologicalPhysiological HomeostasisPhysiological ProcessesPopulationPopulation CharacteristicsPostdocPostdoctoral FellowPosterior Lobe of the Pituitary GlandPosterior Pituitary GlandProductivityProliferatingPropertyREM SleepRecombinant OxytocinRegulationResearch AssociateRhombencephalic SleepRoleSignal TransductionSignal Transduction SystemsSignalingSleepSliceSocial BehaviorSocial HierarchySocial InteractionSynaptic TransmissionSystemSystematicsTestingThalamic structureThalamusThymusThymus GlandThymus ProperThymus Reticuloendothelial SystemTissue-Specific Differential Gene ExpressionTissue-Specific Gene ExpressionWaterWorkbiological signal transductionbusiness-friendly environmentcell typechildrearingcollaborative atmospherecollaborative environmentcomputational modelingcomputational modelscomputer based modelscomputerized modelingcooperative studydreaming sleepelectrophysiologicalendocrine gland/systemexperienceexperimentexperimental researchexperimental studyexperimentsfeedingfirehippocampalhomotypical cortexhypothalamicimagingin vivointeractive atmosphereinteractive environmentinterdisciplinary atmosphereinterdisciplinary environmentisocortexlactatinglactationalmagnocellularneocorticalneopalliumneural circuitneural circuitryneural controlneural regulationneurocircuitryneuromodulationneuromodulatoryneuronalneuroregulationnew approachesnext generationnon rapid eye movementnon-REMnon-rapid eye movementnonREMnonrapid eye movementnovelnovel approachesnovel strategiesnovel strategyoptogeneticsparaventricular nucleusparvocellularpathwaypeer-group atmospherepeer-group environmentpost-docpost-doctoralpost-doctoral traineeposterior lobe of pituitaryposterior pituitaryrapid eye movement sleepreceptive fieldrenalresearch associatesresponsesensorsleep behaviorsleep habitsleep patternsleep routinesleep schedulesleep/wake behaviorsleep/wake patternssocialsocial contactsocial learningsocial rolesociobehaviorsociobehavioralspatial and temporalspatial temporalspatiotemporalstudent trainingsupraoptic nucleussynaptic circuitsynaptic circuitrythalamicthymocytetoolvascular
Description preview
Project Summary (Project 4, Co-PIs: Buzsaki, Froemke, Lin, Tsien)
The spatiotemporal scales of oxytocin (OXT) modulation in the central nervous system remain unclear, and the
actions on downstream targets and mechanisms of upstream control are poorly understood especially compared
to other modulators. Here we measure signals from next-generation…
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