grant
Neural circuit mechanisms underlying pubertal timing
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Jul 2025Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY2025ASDAcademiaAcuteAddressAdrenal GlandsAdrenalsAgeAnimalsArchitectureArg-Phe-NH2AutismAutistic DisorderAutomobile DrivingBehavioralBiologicalBrainBrain Nervous SystemBrain regionCNS plasticityCannot achieve a pregnancyCeliac DiseaseCeliac SprueCell BodyCell CountCell DeathCell NumberCellsChronicCoeliac DiseaseComplexConstitutionDelayed PubertyDevelopmentDifficulty conceivingDisinhibitionEarly Infantile AutismEncephalonEndocrine Gland SecretionEngineering / ArchitectureEnvironmentFSH-Releasing HormoneFacultyGeneticGluten EnteropathyGluten-Sensitive EnteropathyGoalsGonadal Steroid HormonesGonadal structureGonadoliberinGonadorelinumGonadotropin Hormone Releasing HormoneGonadotropin-Releasing HormoneHPG axisHealthHormonal ChangeHormonesHumanHypothalamic HormonesHypothalamic structureHypothalamusInfantile AutismInfertilityKISS1KISS1 Metastasis SuppressorKISS1 geneKanner's SyndromeKiSS-1KnowledgeLH-FSH Releasing HormoneLH-Releasing HormoneLHFSH Releasing HormoneLabelLaboratoriesLifeLuliberinLuteinizing Hormone-Releasing FactorMGC39258Malignant Ovarian NeoplasmMalignant Ovarian TumorMalignant Tumor of the OvaryMalignant neoplasm of ovaryMammaliaMammalsMapsMeasuresMediatingMetastinMethodsMiceMice MammalsModelingModern ManMolecularMolecular GeneticsMurineMusNerve CellsNerve UnitNervous System DiseasesNervous System DisorderNeural CellNeural TransmissionNeurobiologyNeurocyteNeurofibromatosis 1Neurofibromatosis INeurologic DisordersNeurological DisordersNeuronal PlasticityNeuronsNon-tropical SprueNontropical SprueOsteoporosisOutputOvary CancerPathologyPeptidesPeripheral NeurofibromatosisPhysiologicPhysiologicalPhysiologyPituitary GonadotropinsPopulationPrecocious PubertyPrepuberal statePubertyPulstiRFamideRecklinghausen Disease of NerveRecklinghausen's diseaseRecklinghausen's neurofibromatosisRecombinant GonadorelinRegulationResearchResearch ResourcesResolutionResourcesRodentRodentiaRodents MammalsRoleSex HormonesSex Steroid HormonesSocial BehaviorSocial ChangeSocial DevelopmentSocial modificationSocial transformationStaining methodStainsStereotypingStimulusSynaptic TransmissionSystemTestingTherapeutic GRHTherapeutic HormoneTimeTrainingType 1 NeurofibromatosisType I NeurofibromatosisViralWorkagesarginylphenylalaninamideautism spectral disorderautism spectrum disorderautistic spectrum disorderbiologiccareercareer developmentcell typecentral nervous system plasticityco-morbidco-morbiditycomorbiditycritical developmental perioddevelopmentaldevelopmental plasticitydrivingfertility cessationfertility lossfollicle stimulating hormone-releasing factorgonadgonadal steroidsgonadotropin releasing factorgonadshypothalamichypothalamic pituitary gonadal axisidiopathic steatorrheain vivoinfertileinsightkisspeptinnecrocytosisneuralneural circuitneural circuitryneural controlneural mechanismneural plasticityneural regulationneurobiologicalneurocircuitryneurological diseaseneuromechanismneuromodulationneuromodulatoryneuronalneuroplasticneuroplasticityneuropsychiatric diseaseneuropsychiatric disorderneuroregulationnovelovarian cancerpost-natal developmentpostnatalpostnatal developmentprepubertalprepubertypreventpreventingpubertal timingpubertal transitionpuberty transitionresolutionssex steroidskillssocialsocial rolesociobehaviorsociobehavioralsuprarenal glandsynaptic circuitsynaptic circuitrytheoriestherapeutic targettooltransition out of pubertyvon Recklinghausen Disease
Description preview
PROJECT SUMMARY
The pubertal transition marks a significant physiological, hormonal, and social change in animals and occurs at
a very stereotyped timepoint within each species. However, the neural circuit mechanisms underlying the
timing of puberty onset remain unknown. More generally, we know little about how the brain orchestrates long-…
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