grant
Neural circuit mechanisms of inflexible drug seeking in a model of HIV infection
Organization DREXEL UNIVERSITYLocation PHILADELPHIA, UNITED STATESPosted 15 May 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY20261,2-Benzisothiazol-3(2H)-one, 1,1-dioxide21+ years oldAIDS VirusAbstinenceAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAcuteAdultAdult HumanAffectAgonistAnimalsBehaviorBehavior ControlBehavioralBehavioral ManipulationBrainBrain Nervous SystemCNS Nervous SystemCentral Nervous SystemChronicCocaineCocaine use disorderCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCorpus StriatumCorpus striatum structureCoupledDREADDsDecision MakingDevelopmentDisturbance in cognitionDrug ExposureDrug usageDrugsElectrophysiologyElectrophysiology (science)EncephalonExposure toExtinctionFaceFailureFemaleGeneral PopulationGeneral PublicGeneticGlutamate ReceptorGlutamatesHIVHIV 1 associated neurocognitive disorderHIV InfectionsHIV associated neurocognitive deficitHIV associated neurocognitive impairmentHIV individualsHIV induced neurocognitive deficitHIV induced neurocognitive impairmentHIV infected individualsHIV infected personsHIV neurocognitive impairmentHIV peopleHIV positive individualsHIV positive peopleHIV viral infectionHIV virus infectionHIV-1 associated neurocognitive deficitHIV-1 associated neurocognitive disorderHIV-1 associated neurocognitive impairmentHIV-1 infectionHIV-associated neurocognitive disorderHistoryHuman Immunodeficiency VirusesIQ DeficitImmunoblottingImpaired cognitionImpairmentImplantInfectionInfection by HIV-1Infection from HIV-1Infection of HIV-1IntakeL-GlutamateLAV-HTLV-IIILabelLymphadenopathy-Associated VirusMaintenanceMedialMediatingMedicationMiceMice MammalsModelingMurineMusNerve CellsNerve UnitNeural CellNeuraxisNeurocognitiveNeurocognitive DeficitNeurocognitive Impairment in HIVNeurocognitive Impairment in HIV-1NeurocyteNeuronsNeurophysiology / ElectrophysiologyNucleus AccumbensOutcomePLWHPWHPatternPerformancePeripheral Nervous SystemPersonsPharmaceutical PreparationsPharmacologyPredispositionPrefrontal CortexQOL improvementReceptor ProteinRecording of previous eventsRegulationRelapseRewardsRiskRodentRodentiaRodents MammalsRoleSaccharinSelf AdministeredSelf AdministrationStriate BodyStriatumSubstance Use DisorderSusceptibilitySystemTestingTrainingVirusVirus-HIVWestern BlottingWestern ImmunoblottingWild Type Mouseadulthoodantiretroviral therapyantiretroviral treatmentbehavioral controlcocaine exposurecocaine rewardcocaine seekingcocaine self-administrationcocaine usecocaine-exposedcognitive controlcognitive dysfunctioncognitive lossdesigner receptors exclusively activated by designer drugsdevelopmentaldrug usedrug/agentelectrophysiologicalexperimentexperimental researchexperimental studyexperimentsexposed to cocaineexposure to cocainefacesfacialflexibilityflexibleglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalinghistorieshuman immunodeficiency virus infectionhumanized micehumanized mouseimprovements in QOLimprovements in quality of lifein vivoindividuals infected with HIVindividuals with HIVindividuals with human immunodeficiency virusinfected with HIVinfected with human immunodeficiency virusintelligence quotient deficitlearning extinctionmGluR2malemetabotropic glutamate receptor 2mouse modelmurine modelneuralneural circuitneural circuitryneurobehavioralneurocircuitryneurocognitive declineneurocognitive impairmentneuronalnext generationnon-drugnondrugpeople infected with HIVpeople infected with human immunodeficiency viruspeople living with HIVpeople with HIVpeople with human immunodeficiency virusprotein blottingpsychostimulant usequality of life improvementreceptorreceptor expressionself-administer cocainesocial rolestimulant usestriatalsubstance use and disordersynaptic circuitsynaptic circuitrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic agent developmenttherapeutic developmenttherapy adherencetherapy complianceuse of stimulantswildtype mouse♀♂
Description preview
Project Summary
Human immunodeficiency virus (HIV) infection frequently co-occurs with cocaine use disorder (CUD). Despite
high rates of psychostimulant use among people living with HIV (PLWH), and the worsening of HIV outcomes by
chronic drug exposure - including increased risk for neurocognitive impairment -, targeted therapeutic strategies
to…
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