grant
Network Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary Hypertension
Organization VANDERBILT UNIVERSITY MEDICAL CENTERLocation NASHVILLE, UNITED STATESPosted 20 May 2022Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY2026Academic Medical CentersActivities of Daily LivingActivities of everyday lifeAddressAsymmetric Septal HypertrophyAttentionAutopsyBiochemical MarkersBiological MarkersBiologyBlood PlasmaBlood VesselsBlood capillariesBody TissuesCardiac DiseasesCardiac DisordersCardiovascular DiseasesCessation of lifeClinicalClinical TrialsCollaborationsComplexCor pulmonaleCross-Over TrialsCrossover TrialsDataDeathDevelopmentDiagnosisDiseaseDisorderDrug TherapyDrugsExperimental ModelsFibrosisGeneticHeart DiseasesHeart failureHereditary ventricular hypertrophyHeterogeneityHistologicHistologicallyHumanHypertrophic CardiomyopathyHypertrophic Obstructive CardiomyopathyIdiopathic Hypertrophic Subvalvular StenosisIdiopathic hypertrophic subaortic stenosisIn SituIndividualIndividual DifferencesLeftLungLung Respiratory SystemMapsMedicationMedicineMethodsMissionModern ManMolecularNHLBINational Heart, Lung, and Blood InstituteNational Institutes of HealthOutcomePathologyPathway interactionsPatientsPatternPharmaceutical PreparationsPharmacological TreatmentPharmacologyPharmacotherapyPhenotypePlacebo ControlPlasmaPlasma SerumPrognosisProteinsPulmonary Heart DiseasePulmonary Heart DisorderPulmonary HypertensionPulmonary Vascular ResistancePulmonary arterial remodelingReportingResearchReticuloendothelial System, Serum, PlasmaSafetySamplingSeveritiesSystemTestingTissuesUnited KingdomUnited States National Institutes of HealthUniversity Medical CentersValidationVariantVariationVascular remodelingVulnerable PopulationsWorkanalytical methodarterial remodelingbio-markersbiobankbiologic markerbiomarkerbiomarker discoverybiorepositorycandidate biomarkercandidate markercapillarycardiac failurecardiopulmonary diseasecardiopulmonary disordercardiovascular disorderclinical heterogeneitycohortdaily living functiondaily living functionalitydevelopmentaldistal pulmonary artery remodelingdrug interventiondrug treatmentdrug/agentendophenotypeexperimentexperimental researchexperimental studyexperimentsfunctional abilityfunctional capacityfunctional statusglobal gene expressionglobal transcription profileheart disorderhemodynamicshigh riskhuman diseasehypertrophic myocardiopathyimpaired pulmonary vascularizationimprovedin silicoindividual patientinnovateinnovationinnovativelung arterial remodelinglung vascular diseasemortalitynecropsynext generationnovelpathwaypharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticsplacebo controlledpostmortemprecision medicineprecision-based medicineprognosticprognosticationprotein expressionprotein protein interactionpulmonarypulmonary arterial hypertensionpulmonary arterioles remodelingpulmonary artery hypertensionpulmonary artery remodelingpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vasculopathypulmonary venous hypertensionrepurposingresponse to therapyresponse to treatmentsexsmall pulmonary artery remodelingtherapeutic candidatetherapeutic responsetherapeutic targettherapy responsetranscriptometreatment responsetreatment responsivenessvalidationsvascularvenulevulnerable groupvulnerable individualvulnerable people
Description preview
ABSTRACT
Pulmonary hypertension (PH) due to left heart failure is a common and highly morbid disease characterized by
molecular, histophenotypic, and clinical heterogeneity that hampers progress in diagnosis and therapeutic target
discovery. Biochemical markers and treatments for left heart failure-PH patients are lacking. Some patients with
left…
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