grant
Neighborhood and individual environmental risk factors in early life and -omics biomarkers for kidney function trajectories across childhood and adulthood
Organization HARVARD PILGRIM HEALTH CARE, INC.Location Canton, UNITED STATESPosted 23 Apr 2026Deadline 22 Apr 2030
NIHUS FederalResearch GrantFY20260-11 years old12-20 years old21+ years oldAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAddressAdolescenceAdultAdult HumanAffectAir PollutantsAir PollutionBiologicalBiological MarkersBiological Specimen BanksBiological Substance BanksBirthBlood BanksBlood PressureCadmiumCardiorenal diseaseCardiorenal dysfunctionCardiorenal syndromeCd elementCells Placenta-TissueChildChild YouthChildhoodChildren (0-21)ChronicChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureClinicalCoupledDataDevelopmentDiagnosisEnrollmentEnvironmentEnvironmental FactorEnvironmental Risk FactorExposure toFaceFetusFutureGestationGoalsGuidelinesHabitsHealthHealth Care CostsHealth CostsHealth protectionHypertensionIndividualInjury to KidneyInvestigatorsKidney DiseasesLeadLifeLife CycleLife Cycle StagesLife StyleLifestyleLinkLong-term Follow-upLongitudinal StudiesLongitudinal SurveysMeasuresMetalsMethodsMolecular FingerprintingMolecular ProfilingMorbidityMothersNational Institutes of HealthNeighborhoodsNephropathyNephrotoxicNon-Invasive DetectionNoninvasive DetectionNormal PlacentomaOutcomePM2.5ParturitionPathway interactionsPb elementPlacentaPlacenta Embryonic TissuePlacentomePlayPopulationPositionPositioning AttributePregnancyPregnant WomenPremature MortalityPreventionProcessProteinsProteomicsPublic HealthRenal DiseaseRenal functionResearchResearch PersonnelResearch ResourcesResearchersResourcesRisk FactorsToxicant exposureTubularTubular formationUnited States National Institutes of HealthVascular Hypertensive DiseaseVascular Hypertensive DisorderWorkacute kidney injuryadolescence (12-20)adulthoodadverse consequenceadverse outcomebio-markersbiologicbiologic markerbiological specimen repositorybiomarkerbiosample repositorybiospecimen bankbiospecimen repositorycandidate biomarkercandidate markerchronic kidney diseaseclinical relevanceclinically relevantcohortcommunity level disadvantagedamage to kidneydevelopmentaldisadvantaged communityearly adulthoodearly life exposureemerging adultenrollenvironmental riskenvironmental stressesenvironmental stressorexpectant motherexpectant womenexpecting motherexpecting womenexposed in uterofacesfacialfetal exposurefine particlesfine particulate matterheavy metal Pbheavy metal leadhigh blood pressurehigh risk grouphigh risk individualhigh risk peoplehigh risk populationhyperpiesiahyperpiesishypertensive diseasehypertensive disorderin uteroin utero exposureindexingindividuals who are pregnantinnovateinnovationinnovativeintra-uterine environmental exposureintrauterine environmental exposurekidney damagekidney developmentkidney disorderkidney dysfunctionkidney functionkidney injurykidney toxicitykidslater in lifelater lifelife courselong-term followuplong-term studylongitudinal outcome studieslongitudinal research studymalleable riskmodifiable riskmolecular profilemolecular signatureneighborhood barrierneighborhood disadvantageneighborhood-level barrierneighborhood-level disadvantagenephrogenesisnephrotoxicitynew markernovelnovel biomarkernovel markerpathwaypediatricpeople who are pregnantpostnatalpregnant femalespregnant motherspregnant peoplepregnant populationsprenatalprenatal exposureprenatally exposedpreservationpreventpreventingprospectiveprotein biomarkersprotein markersproteomic signaturerenal damagerenal disorderrenal dysfunctionrenal injuryresidenceresidential buildingresidential sitesocialsocial determinantssocial health determinantssocio-demographicssociodemographicssociodeterminantspecimen bankspecimen repositorythose who are pregnanttoxic exposuretoxic metalunbornurinarywomen who are pregnantyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
Chronic kidney disease (CKD) and hypertension (HTN) are substantial public health concerns in the US and
are important risk factors for other adverse outcomes including acute kidney injury and premature mortality.
CKD and HTN are typically diagnosed later in life, yet our understanding of the prenatal and early life…
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