NEI Center Core Grant for Vision Research

Overall Core Project Summary
The overall aim of the Cole Eye Institute (CEI) Core Facilities for Vision Research is to facilitate the analysis of the structure,
function and disease mechanisms that affect the visual system by providing centralized assess to shared resources. The Core
Facilities will provide resources, expertise and equipment to aid in the research endeavors of a vibrant and highly
collaborative group of vision science investigators at CEI of the Cleveland Clinic Foundation. The long-term goal of the
investigators served by this grant is to prevent blindness and restore vision in diseases such as Retinopathy of Prematurity,
Diabetic Retinopathy. AMD and Inherited Retinal Degenerations. To this end we have developed a series of Core modules
that will continue to provide state-of-the-art instrumentation and technologies required for vision research. The three Core
modules are: (1) Ocular Imaging Core; (2) Functional Vision Core; and (3) Molecular Informatics Core. These Cores contain
equipment that is maintained and operated by highly skilled technicians that are supervised by established research scientists.
Consolidating these technologies into the three Cores allows us to bring these techniques and skills to all potential users in
our program, which we anticipate will continue to increase productivity in the user laboratories and avoid duplication of
equipment and effort. Successful operation of these three Cores will bring the best of these technologies to each of the NEI
RO1 supported laboratories in this institution. We also envision that these Core modules will continue to enhance and sustain
the collaborative scientific environment that is a strong feature of the CEI Vision research group. The Cores will also
enhance productivity among the participating investigators as in the previous grant cycle and allow junior investigators to
have access to services and research strategies that will help generate preliminary data to support new RO1 applications.

Grant Number: 5P30EY025585-10
NIH Institute/Center: NIH
Principal Investigator: BELA ANAND-APTE