grant
Natural history and evaluation of abnormal or nonreportable NIPT results and its association with maternal neoplasia
Organization NATIONAL HUMAN GENOME RESEARCH INSTITUTELocation UNITED STATES
NIHUS FederalResearch GrantFY2025Active Follow-upAdrenal Cortex CarcinomaAdrenal Cortical CarcinomaAdrenocortical CarcinomaAlgorithmsAmniocentesisAneuploidAneuploidyAsianAwarenessBartholin-Patau syndromeBenignBiochemistryBiocompatible MaterialsBiologicalBiological ChemistryBiomaterialsBlackBlack raceBlindedBloodBlood PlasmaBlood Plasma CellBlood Reticuloendothelial SystemBlood SerumBreast CancerCanadaCancersCells Placenta-TissueChorionic Villi BiopsyChorionic Villi SamplingChromosomal GainChromosomal LossChromosomesClinicalClinical DataClinical ManagementClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionColorectal CancerDNADNA SequenceDNA analysisDNA seqDNA sequencingDNAseqDeoxyribonucleic AcidDetectionDiagnosisDiagnosticDiagnostic testsEchographyEchotomographyEligibilityEligibility DeterminationEnrollmentEvaluationFetusFibroid UterusGeneticGenomic TestingGerminoblastic SarcomaGerminoblastomaGestationGuidelinesHematologic Body SystemHematologic Organ SystemHematopoietic Body SystemHematopoietic SystemHispanicHospitalsImageIndividualInternationalIsraelKaryotypeLaboratoriesLymphomaMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMalignantMalignant - descriptorMalignant Breast NeoplasmMalignant LymphomaMalignant NeoplasmsMalignant TumorMapsMedicalMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedical InspectionMedical UltrasoundMosaicismNMR ImagingNMR TomographyNatural HistoryNeonatalNeoplasmsNon-HispanicNon-MalignantNonhispanicNormal PlacentomaNot Hispanic or LatinoNuclear Magnetic Resonance ImagingOncologistParticipantPatau syndromePatau's syndromePatternPhysical ExaminationPhysiciansPlacentaPlacenta Embryonic TissuePlacentomePlasmaPlasma CellsPlasma SerumPlasmacytesPositive Test ResultPostpartum PeriodPredictive ValuePregnancyPregnant WomenPrenatal careProfessional OrganizationsProtocol ScreeningProviderProxyPublishingRaceRacesReportingReticuloendothelial System, Serum, PlasmaReticulolymphosarcomaRetrospective StudiesRiskSamplingScreening for cancerSerumTest ResultTestingTimeTime StudyTrisomy 13Trisomy 13 SyndromeTwin Multiple BirthTwinsUltrasonic ImagingUltrasonogramUltrasonographyUltrasound DiagnosisUltrasound Medical ImagingUltrasound TestUnited StatesUterine Body FibroidUterine Body LeiomyomaUterine Corpus FibroidUterine Corpus LeiomyomaUterine FibroidsUterine FibromaUterine LeiomyomaUterus FibromaWomanWorkZeugmatographyacronymsactive followupanalyze DNAbiologicbiological materialcancer diagnosiscancers that are rarecell free DNAcell free DNA profilingcell free DNA screeningcell free DNA-based assaycell free circulating DNAcell-free DNA assaycell-free DNA testcfDNA assaycfDNA profilingcfDNA screeningcfDNA testcfDNA-based assaychorionic villous samplingchromosome 13 trisomychromosome 13 trisomy syndromecirculating DNAclinical careclinical centerclinical sequencingclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellscohortconferencecontinuing medical educationconventioncorpus uteri fibroidcorpus uteri leiomyomadetection methoddetection proceduredetection techniquediagnostic ultrasoundearly cancer detectionenrollexpectant motherexpectant womenexpecting motherexpecting womenfetalfollow upfollow-upfollowed upfollowupgenome based testinggenome testinggenomic DNA testinggenomic based testinggenomic clinical testinggenomic profiling testinggenomic screening testhematopoietic cell cloneshematopoietic stem cell clonalityhigh riskimagingindividuals who are pregnantkaryogrammalignancymalignant breast tumormeetingmeetingsmosaic diseasesmosaic disordersmultidisciplinaryneoplasianeoplasm/cancerneoplastic growthnonmalignantobstetric carepeople who are pregnantphysical examinationsplasmocytepost-partumpregnancy carepregnantpregnant femalespregnant motherspregnant peoplepregnant populationsprenatalprenatal appointmentprenatal checkupprenatal screeningprenatal testingprenatal visitprofessional associationprofessional membershipprofessional societyracialracial backgroundracial originrare cancerrare malignancyrare tumorreference assemblyreference genomescreeningscreening cancer patientsscreeningssonogramsonographysound measurementsummitsymposiasymposiumtest using cell free DNAtests using cfDNAthose who are pregnanttumorultrasoundultrasound imagingultrasound scanningunbornuterus leiomyomawhole body imagingwhole body scanningwomen who are pregnant
Description preview
Since it became clinically available, noninvasive screening for fetal aneuploidy by sequencing cell-free (cf) DNA fragments that circulate in maternal blood has disrupted established global paradigms for prenatal care. In general, these tests work by mapping sequenced DNA fragments and determining if there are excess or reduced copy numbers…
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