grant
National Center of Rabbit Models for Translational Research
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AdoptionAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesBiologic ModelsBiological ModelsBiomedical ResearchBody SizeBreedingBypassCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCaringCas nuclease technologyClinicalClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyCochleaCochlear OrganCommon Rat StrainsCommunicable DiseasesCommunitiesCoupledCryofixationCryopreservationDNA RecombinationDevelopmentDiseaseDisorderDomestic RabbitES cellEducational workshopEmbryologyEngineered GeneFamily suidaeFertilization in VitroGEM modelGEMM modelGene Transfer TechniquesGenerationsGenesGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic RecombinationGenetically Engineered MouseGraefe-Usher syndromeGrantHPV VaccineHallgren syndromeHeart VascularHousingHumanHuman Papilloma Virus VaccineHuman papillomavirus VaccineHyperlipemiaHyperlipidemiaImmunologyInfantInfectious DiseasesInfectious DisorderIntegraseInvestigatorsKnock-inKnock-outKnockoutMaintenanceMediatingMiceMice MammalsMissionModel SystemModelingModern ManMouse ES CellMouse ESCMouse Embryonic ProgenitorMouse Embryonic Stem CellsMurineMusNational Institutes of HealthNeurologicNeurologicalOryctolagus cuniculusPhenotypePigsPoint MutationPositionPositioning AttributeProcessProteinsPublishingRabbitsRabbits MammalsRatRats MammalsRattusRecombinant DNA TechnologyRecombinationReproductionResearchResearch PersonnelResearch PriorityResearch ResourcesResearchersResourcesRetinaRodentRodentiaRodents MammalsSuidaeSurgical ModelsSwineTargeted ResearchTechnical ExpertiseTechniquesTechnologyTest-Tube FertilizationTestingTherapeuticTimeTrainingTransgenesisTransgenic OrganismsTranslational ResearchTranslational ScienceUnited StatesUnited States National Institutes of HealthUsher SyndromeUsher's syndromeVariantVariationWorkshopcirculatory systemclinical relevanceclinically relevantcold preservationcold storagecostdevelopmentaldystrophia retinae pigmentosa-dysostosis syndromedystrophia retinae-dysacousis syndromeembryo derived stem cellembryonal stem cellsembryonic progenitorembryonic stem cellgenetically engineeredgenetically engineered mouse modelgenetically engineered murine modelgenome editinggenomic editinghuman diseasehuman modelimprovedinterestknockinknockout genelife spanlifespanmESCmodel of animalmodel of humanmouse modelmurine ES cellsmurine ESCmurine embryonic progenitormurine embryonic stem cellmurine modelnon-human primatenonhuman primatenovelporcinepreservationreference assemblyreference genomeretinitis pigmentosa-congenital deafness syndromestem cell of embryonic originsuidtechnical skillstransgenictranslation researchtranslational investigationtranslational model
Description preview
PROJECT SUMMARY: Rabbits offer great potential as translationally relevant models of human disease for
many biomedical research applications thanks to their evolutionarily closeness to humans, favorable
reproduction features, relatively long lifespan which allows for clinically relevant studies, a body size that is
similar to that of human infants…
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