grant

Nanoparticle-Based Tracking of Retinal Ganglion Cell Transplant

Organization CASE WESTERN RESERVE UNIVERSITYLocation CLEVELAND, UNITED STATESPosted 1 Jul 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026AddressAffectAge related macular degenerationAge-Related MaculopathyAnimalsApoptoticAreaAssayAwardBehaviorBioassayBiocompatible MaterialsBiological AssayBiomaterialsBiomedical EngineeringBlindnessBody TissuesCell BodyCell Communication and SignalingCell CountCell NumberCell SignalingCell TherapyCell TransplantationCellsChargeClinicCommunitiesContrast AgentContrast DrugsContrast MediaCorneaCranial Nerve IICranial Nerve II DiseasesCranial Nerve II DisorderCristobaliteDataDegenerative Neurologic DisordersDiseaseDisorderDoppler OCTEngineeringEyeEye diseasesEyeballFaceFacultyGelGlaucomaGoalsGoldHortega cellICP-MSImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodIn VitroInductively Coupled Plasma Mass SpectrometryInjectionsInjuryIntracellular Communication and SignalingInvestigationInvestigatorsKnowledgeLabelLaboratoriesLaser ElectromagneticLaser RadiationLasersLeannessLocationMentorsMethodsMiceMice MammalsMicrogliaModelingMolecularMurineMusNatural regenerationNeonatalNerve CrushNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeural-Optical LesionNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsOCT TomographyOilsOphthalmologyOphthalmoscopyOptic NerveOptic Nerve DiseasesOptic NeuropathyOptical Coherence TomographyOutcomeOuter pigmented layer of retinaPatientsPeripheralPhasePigment cell layer of retinaPigmented layer of retinaPrevalenceProcessPrognosisRadiopaque MediaReactionRegenerationResearchResearch PersonnelResearch ResourcesResearchersResolutionResourcesRetinaRetinal Blood VesselsRetinal DegenerationRetinal Ganglion CellsRetinal Pigment EpitheliumRetinal VesselsRetinal pigment epithelial cellsRodentRodentiaRodents MammalsSandScanningSecond Cranial NerveSecond Cranial Nerve DiseasesSi elementSightSignal TransductionSignal Transduction SystemsSignalingSilanesSilicaSiliconSilicon DioxideSiteStructure of retinal pigment epitheliumSurfaceTestingTherapeuticThickThicknessThinnessTimeTissuesTrainingTranslatingTransplantationTreatment EfficacyTridymiteUniversitiesVisionVisualizationage dependent macular degenerationage induced macular degenerationage related macular diseaseage related macular dystrophybeta Actinbio-engineeredbio-engineersbioengineeringbiological engineeringbiological materialbiological signal transductioncareercell based interventioncell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapycellular transplantclinical applicabilityclinical applicationcornealdamage to retinadegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdegenerative retina diseasesdesigndesigningdiagnostic approachdiagnostic strategydisease modeldisorder modelexperimentexperimental researchexperimental studyexperimentseye disorderfacesfacialgitter cellglaucomatousgold nano particlegold nanoparticleimagingimaging programimprovedin vivoinjuriesinterdisciplinary collaborationintervention efficacymaterials sciencemesogliamicroglial cellmicrogliocytemolecular imagingmolecule imagingnano goldnano particlenano-sized particlenanoGoldnanoparticlenanorodnanosized particleneurodegenerative illnessnew diagnosticsnext generation diagnosticsnovelnovel diagnosticsocular diseaseocular disorderophthalmopathyoptic nerve disorderoptical Doppler tomographyoptical coherence Doppler tomographyperivascular glial cellpre-clinicalpre-clinical studypreclinicalpreclinical studyregeneraterepairrepairedresolutionsrestore sightrestore visionretina blood vessel structureretina degenerationretinal damageretinal degenerativeretinal degenerative diseasesretinal ganglionretinal imagingretinal vascular networkretinal vascular structureretinal vasculaturesecond cranial nerve disordersenile macular diseasesight restorationskillssuccesstherapeutic efficacytherapy efficacytooltransdisciplinary collaborationtransplanttransplant therapytransplant treatmenttransplantation therapytransplantation treatmentuptakevision lossvision restorationvisual functionvisual lossβ-Actin
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Project Summary/Abstract
There is a critical need to translate retinal ganglion cell (RGC) therapies from lab to clinic, particularly cell

transplant therapies to repair degenerated eye tissues and restore visual function. RGC transplant has great

potential in treating degenerative retinal and optic nerve diseases, but key pre-clinical studies are…

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Nanoparticle-Based Tracking of Retinal Ganglion Cell Transplant — CASE WESTERN RESERVE UNIVERSITY | UNITED STATES | Jul | Dev Procure