grant
Myeloid-Derived Suppressor Cells in Immunological Endotyping and Intervention of Chronic Critical Illness after Sepsis
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AI systemArtificial IntelligenceAutomobile DrivingBlood leukocyteCatabolismCell BodyCellsChromatinChronicClinicalComputer ReasoningCritical IllnessCritically IllDNA MethylationDataDiagnosisDrug TherapyDrugsDysfunctionEarly DiagnosisExhibitsFDA approvedFunctional disorderGenomicsGoalsHeterogeneityHospital AdmissionHospitalizationHospitalsImmune MarkersImmune responseImmunochemical ImmunologicImmunologicImmunologic MarkersImmunologicalImmunologicallyImmunologicsImmunosuppressionImmunosuppression EffectImmunosuppressive EffectInfectionInflammationInterventionKnowledgeLaboratoriesLaboratory ResearchLength of StayLeukocytesLeukocytes Reticuloendothelial SystemLifeMachine IntelligenceMarrow leukocyteMeasurementMedicationMultiomic DataMyeloid-derived suppressor cellsMyelopoiesisNucleic AcidsNumber of Days in HospitalOperative ProceduresOperative Surgical ProceduresOrganOutcomePathologicPathway interactionsPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPharmaceutical PreparationsPharmacological TreatmentPharmacotherapyPhysiopathologyProbabilistic ModelsProbability ModelsProteinsProteomicsRoleSample SizeSepsisStatistical ModelsSupportive TherapySupportive careSurgicalSurgical InterventionsSurgical ProcedureSyndromeT-CellsT-LymphocyteTherapeutic InterventionWhite Blood CellsWhite CellWorkafter sepsisafter septicantisepsis treatmentclinical developmentclinical predictorsdrivingdrug candidatedrug interventiondrug treatmentdrug/agentearly biomarkersearly detectionearly detection biomarkersearly detection markerseffective interventionfollowing sepsisfollowing septicglobal gene expressionglobal transcription profilehospital dayshospital length of stayhospital stayhost responseimmune suppressionimmune suppressive activityimmune suppressive functionimmune system responseimmune-based biomarkersimmunological biomarkersimmunological markersimmunological statusimmunoresponseimmunosuppressedimmunosuppressive activityimmunosuppressive functionimmunosuppressive myeloid cellsimmunosuppressive responseimprovedindividuals with sepsisinnovateinnovationinnovativeintervention therapymetabolism measurementmetabolomicsmetabonomicsmortalitymultiomicsmultiple omic datamultiple omicsmyeloid suppressor cellsmyeloid-derived suppressive cellspanomicspathogenpathophysiologypathwaypatient oriented outcomespatients with sepsispeople with sepsispharmaceutical interventionpharmacological interventionpharmacological therapypharmacology interventionpharmacology treatmentpharmacotherapeuticspost sepsispost septicprecision medicineprecision-based medicineprogramsresponsesepsis caresepsis groupssepsis interventionssepsis managementsepsis patientssepsis populationsepsis subjectssepsis therapeuticssepsis therapysepsis treatmentseptic groupseptic individualsseptic patientsseptic peopleseptic populationseptic subjectseptic therapyseptic treatmentsocial rolestatistical linear mixed modelsstatistical linear modelssubjects with sepsissuppressive myeloid cellssurgerytherapeutically effectivethymus derived lymphocytetranscriptometranscriptomicstreat sepsiswhite blood cellwhite blood corpuscle
Description preview
ABSTRACT
Sepsis is a life-threatening condition characterized by a dysregulated immune response to infection leading to
organ dysfunction. It frequently occurs in hospitalized patients undergoing surgical procedures and is associated
with prolonged hospital stays and increased mortality. Despite improved in-hospital survival, 30-50% of surgical…
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