grant
Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point Mutations
Organization DIVISION OF CLINICAL SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY20251.beta.-D-ArabinofuranosylcytosineABC20ABCB1ABCB1 geneARA-cellAfter CareAfter-TreatmentAftercareAlexanAnti-OncogenesAntioncogenesArabineArabinofuranosylcytosineArabinosylcytosineAracytidineAracytinAracytineAssayBioassayBiologic ModelsBiological AssayBiological ModelsCancer Suppressor GenesCancersCell LineCell divisionCellLineCellular OncogeneChemoresistanceChromosomal RearrangementChromosomal dislocationChromosomal translocationClonal ExpansionCytarabineCytarabinumCytarbelCytidineCytosarCytosar-UCytosarUCytosine ArabinosideCytosine RibonucleosideCytosine RibosideCytosine-.beta.-arabinosideDNADNA Insertion ElementsDNA mutationDeoxyribonucleic AcidDevelopmentEmerogenesErpalfaEventFDA approvedGP170Gene TranscriptionGeneralized GrowthGenesGenetic ChangeGenetic TranscriptionGenetic TranslocationGenetic defectGenetic mutationGenomic SegmentGenotoxinsGoalsGrowthIn VitroKinasesLeurocristineMDR-1MDR1MDR1 ProteinMalignantMalignant - descriptorMalignant CellMalignant NeoplasmsMalignant TumorManuscriptsMethotrexateMethotrexate MethylaminopterinMethotrexatumMetotrexatoMitochondrial DNAModel SystemMolecularMultidrug Resistance 1Multidrug Resistance Gene-1Multidrug Resistance Gene-1sMultidrug Resistance ProteinsMultidrug Resistant ProteinsMutagensMutationNon-Polyadenylated RNANuclearOnco-Suppressor GenesOncogenes-Tumor SuppressorsOncogenicP-GPP-GlycoproteinP-Glycoprotein 1 GenePGY-1 ProteinPGY1PhosphorylationPhosphotransferase GenePhosphotransferasesPoint MutationProductionPropertyProtein PhosphorylationProto-OncogenesPublishingRNARNA ExpressionRNA Gene ProductsRecessive OncogenesRecurrenceRecurrentReproducibilityResistanceResistance developmentResistant developmentRibonucleic AcidSingle Base PolymorphismSingle Nucleotide PolymorphismStrains Cell LinesT leukemia cellT-ALL cellTarabine PFSTissue GrowthTranscriptionTransphosphorylasesTumor Suppressing GenesTumor Suppressor GenesUdicilVincristineVincrystineacute T-cell lymphoblastic leukemia cellacute T-cell lymphocytic leukemia cellc-ONCcancer cellchemoresistantchemotherapychemotherapy resistancechemotherapy resistantchromosome dislocationchromosome translocationcultured cell linedeveloping resistancedevelopmentalfusion genegenome mutationgenome segmentgenomic regiongenotoxic agentgenotoxicityin vitro Assayinsertion elementinsertion sequenceleukemiamalignancymtDNAneoplasm/cancernoveloncosuppressor geneontogenyoxovincaleukoblastinepost treatmentpreventpreventingprotooncogeneresistantsingle nucleotide variant
Description preview
It is well-established that many leukemias are initially sensitive to chemotherapy, but ultimately develop resistance. We have generated a panel of T-ALL cell lines, and have generated chemotherapy-resistatn derivatives of these cell lines, through continued growth in the presence of chemotherapy agents. The chemotherapy resistant cell lines have…
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