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MuRF1 substrates and mechanisms of skeletal muscle atrophy

Organization OKLAHOMA MEDICAL RESEARCH FOUNDATIONLocation OKLAHOMA CITY, UNITED STATESPosted 1 Apr 2024Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAPF-1ATP-Dependent Proteolysis Factor 1AccelerationAffinityAgingAnterior Tibial MuscleAreaAtrophicAtrophyCancersCardiovascular DiseasesCoupledCytoplasmDataDenervationDesminDeuterium OxideDiglycineDiseaseDisorderE3 LigaseE3 Ubiquitin LigaseElectroporationFiberFibroblast Intermediate Filament ProteinsGastrocnemius MuscleGlycyl-GlycineGlycylglycineHMG-20Heavy WaterHigh Mobility Protein 20HindlimbHumanImmobilizationIntermediate Filament ProteinsInvestigationKO miceKidney FailureKidney InsufficiencyKnock-out MiceKnockout MiceKnowledgeL-LysineLabelLengthLinkLiquid ChromatographyLiteratureLysineMacropainMacroxyproteinaseMalignant NeoplasmsMalignant TumorMapsMeasuresMediatingMetabolic Protein DegradationMiceMice MammalsModern ManModificationMulticatalytic ProteinaseMurineMusMuscleMuscle AtrophyMuscle FibersMuscle TissueMuscular AtrophyMyotubesN-GlycylglycineN-glycyl-glycineNerve DegenerationNeuron DegenerationNull MouseOutcomePharmaceutical AgentPharmaceuticalsPharmacologic SubstancePharmacological SubstancePlasmidsPreventionProcessProsomeProteasomeProteasome Endopeptidase ComplexProtein TurnoverProteinsProteomicsProteosomePublicationsRegulatory Protein DegradationRenal FailureRenal InsufficiencyReportingRestRhabdomyocyteRodentRodentiaRodents MammalsRoleSarcomeresScientific PublicationSiteSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSkeletinStriated MusclesTestingThick FilamentTimeTranscriptional ControlTranscriptional RegulationUbiquitinUbiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3UpregulationValidationVoluntary MuscleWater-d2cardiovascular disorderdevelop therapydrug candidatedrug developmenteffective therapyeffective treatmentelectroporative deliverygastrocnemiusgene electrotransferin vivoinsightintervention developmentmalignancymulticatalytic endopeptidase complexmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurological degenerationneuronal degenerationnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetorthopedic freezingoverexpressoverexpressionpharmaceuticalpreventpreventingprotein degradationresponseselective expressionselectively expressedskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingsocial roletandem mass spectrometrytherapy developmenttibialis anteriortibialis anterior muscletreatment developmentubiquitin-protein ligasevalidations

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SUMMARY
Skeletal muscle atrophy continues to be a serious consequence of many diseases and conditions for which there
is no effective treatment. The E3 ubiquitin ligase, MuRF1 (Trim63), is selectively expressed in striated muscle
and has been shown to be elevated in a myriad of atrophy-inducing conditions in both rodent and human muscle
and thus…

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MuRF1 substrates and mechanisms of skeletal muscle atrophy — OKLAHOMA MEDICAL RESEARCH FOUNDATION | UNITED STATES | Apr | Dev Procure