grant
Multiscale genomic decryption of regulatory DNA
Organization UNIVERSITY OF CALIFORNIA, SAN DIEGOLocation LA JOLLA, UNITED STATESPosted 1 Aug 2024Deadline 30 Jun 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAffectAffinityBasal Transcription FactorBasal transcription factor genesBindingBinding SitesBiologicalCell BodyCell Communication and SignalingCell SignalingCellsChromatinCombining SiteDNADNA BindingDNA Binding InteractionDNA boundDNA mutationDNA-Dependent RNA Polymerase IIDataDefectDeoxyribonucleic AcidDevelopmentDiseaseDisorderDistalEnhancer ElementsExpression SignatureFrequenciesGene Action RegulationGene Expression ProfileGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGene variantGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic DiversityGenetic Enhancer ElementGenetic TranscriptionGenetic VariationGenetic defectGenetic mutationGenomeGenomicsHumanIndividualIntracellular Communication and SignalingLaboratoriesLocationMeasurementModelingModern ManMolecularMolecular InteractionMutationNucleic Acid Regulator RegionsNucleic Acid Regulatory SequencesNucleotidesPlayPositionPositioning AttributePredispositionRNA ExpressionRNA Polymerase BRNA Polymerase IIReactive SiteRegulatory ElementRegulatory RegionsReporterResearchRoleSignal TransductionSignal Transduction SystemsSignalingSpecific qualifier valueSpecifiedStimulusStructureSusceptibilityTechnologyTranscriptionTranscription Factor Proto-OncogeneTranscription InitiationTranscription Initiation SiteTranscription Start SiteTranscription factor genesWorkallelic variantbasebasesbiologicbiological signal transductionchromatin modificationdevelopmentalenhancer sequenceepigenetic biomarkerepigenetic markerepigenetic profilinggene expression patterngene expression signaturegene locusgenetic enhancer sequencegenetic locusgenetic regulatory elementgenetic variantgenome mutationgenomic locationgenomic locusgenomic varianthuman DNAinsightnovelpromoterpromotorrecruitsocial rolethree dimensionaltranscription factortranscriptional profiletranscriptional signature
Description preview
Project Summary/Abstract:
Regulatory DNA encodes signals that are recognized by transcriptional regulators to drive development- and
stimulus-specific patterns of gene expression. While individual DNA binding sites recognized by transcription
factors are often short and promiscuous in the genome, functional regulatory elements usually contain…
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