grant
Multimodal AI for aortic disease
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 30 Sept 2025Deadline 29 Sept 2030
NIHUS FederalResearch GrantFY20253-D3-D structure3-Dimensional3-dimensional structure3D3D structureAI systemAddressAgeAgingAortaAortic DiseasesArchitectureArtificial IntelligenceBlood VesselsCAT scanCT X RayCT XrayCT imagingCT scanCalcifiedCardiacCardiologyCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCatalogsChestClassificationClinicalClinical geneticsCollagenComplexComputed TomographyComputer ReasoningConvNetDataData ReportingData SetDepositDepositionDiagnosticDiameterDimensionsDiseaseDisease ProgressionDisorderElastinEngineering / ArchitectureEnvironmental FactorEnvironmental Risk FactorEventFiberFoundationsFutureGWA studyGWASGeneral RadiologyGeneticGenetic DeterminismGeometryHeart VascularHumanICD-9ImageInterventionInvestigationJointsLearningMachine IntelligenceMeasurementMedical GeneticsMedicineMentorshipMethodsModelingModern ManMultimodal MLMultimodal machine learningOrganOutcomeParticipantPatternPerformancePhenotypePlayPopulationPredictive ValueProcessProtocolProtocols documentationRadiologyRadiology SpecialtyReportingResearchRisk AssessmentRoleRuptureSamplingScanningShapesStructureSystematicsTextThoraceThoracicThoracic aortaThoraxTimeTomodensitometryTrainingVariantVariationVascular agingWorkWork LoadWorkloadX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyage associatedage associated alterationsage associated changesage associated effectsage correlatedage correlated alterationsage correlated changesage dependentage dependent alterationsage dependent changesage effectage induced alterationsage induced changesage linkedage relatedage related alterationsage related changesage related effectsage specificage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging effectaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageaortic archaortic disorderauto-segmentationautoencoderautoencoding neural networkautomated segmentationautomatic segmentationautosegmentationbiobankbiorepositorycalcificationcardiovascular disordercardiovascular healthcardiovascular riskcardiovascular risk factorcatalogcatscanchanges with agecirculatory systemcomputed axial tomographycomputer tomographycomputerized axial tomographycomputerized tomographyconvolutional networkconvolutional neural netsconvolutional neural networkcrosslinkdata representationdata representationsdesigndesigningdiagnostic tooldisease classificationdisease riskdisorder classificationdisorder riskenvironmental riskgene locusgenerative modelsgenetic determinantgenetic informationgenetic locusgenome wide associationgenome wide association scangenome wide association studygenomewide association scangenomewide association studygenomic datagenomic datasetgenomic locationgenomic locusgeometric structurehemodynamicsimagingimaging geneticsimaging studyimpact of ageimprovedindexinginfluence of ageinnovateinnovationinnovativeinsightlife spanlifespanmulti-modalitymultimodal learningmultimodal modelingmultimodalitynon-contrast CTnoncontrast CTnoncontrast computed tomographynosologynovelpolygenic predictorspolygenic scoresprognosticprognostic abilityprognostic powerprognostic significanceprognostic toolprognostic utilityprognostic valuesimulationskillssocial rolestructural geometrythree dimensionalthree dimensional structuretime usetoolvascularvasculature agingwhole genome association analysiswhole genome association study
Description preview
Project Summary/Abstract
The aorta is central to cardiovascular health, with its structure and function significantly influencing disease risk
and organ damage. Aging leads to structural changes such as elastin degradation, fiber rupture, collagen
deposition, and calcification, resulting in adverse hemodynamic effects, including increased cardiac…
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