grant
Multidisciplinary approach to study of patients with Severe Alcoholic Hepatitis Undergoing Liver Transplantation
Organization JOHNS HOPKINS UNIVERSITYLocation BALTIMORE, UNITED STATESPosted 1 Feb 2019Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AccountingActive Follow-upAcuteAddressAdmissionAdmission activityAffectAlcohol DrinkingAlcohol associated hepatitisAlcohol consumptionAlcohol dependenceAlcohol hepatitisAlcohol induced hepatitisAlcohol related hepatitisAlcoholic HepatitisAlcoholic Liver DiseasesAreaBioethicsBiomedical EthicsCaringCessation of lifeClinicalCommunitiesConsensusDataDeathDeath RateDevelopmentDiagnosisEconomic IncomeEconomical IncomeEnsureEtOH drinkingEtOH useEthanol-induced hepatitisEthicsEvaluationFutureGeneral PopulationGeneral PublicGeographic AreaGeographic LocationsGeographic RegionGeographical LocationGoalsGrantGroups at riskHealth Care ProfessionalHealth Catchment AreaHealth ProfessionalHealth Service AreaHepatic TransplantationImprove AccessIncomeIndividualInferiorInformed ConsentInfrastructureInsuranceInterventionLifeLiteratureLiver GraftingLiver TransplantMeasuresMedicalNIAAANational Institute on Alcohol Abuse and AlcoholismNational Institutes of HealthNon-HispanicNonhispanicNot Hispanic or LatinoOutcomePatient CarePatient Care DeliveryPatient advocacyPatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPatientsPatternPeople at riskPerceptionPersons at riskPhasePhenX ToolkitPhenotypes and eXposures ToolkitPhenxPilot ProjectsPoliciesPopulationPopulations at RiskPrivatizationProcessProspective cohortProspective, cohort studyProviderQOCQuality of CareReactionRecommendationRefractoryRelapseResearchResearch ResourcesResolutionResourcesSelection CriteriaService areaSpecialistSubstance Use DisorderTransplant RecipientsTransplantationUnited StatesUnited States National Institutes of HealthUniversitiesWaiting ListsWorkaccess gapsactive followupalcohol addictionalcohol dependencyalcohol dependentalcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol ingestionalcohol intakealcohol product usealcohol related liver diseasealcohol related researchalcohol researchalcohol usealcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic beverage consumptionalcoholic drink intakealcoholic liver injurycandidate selectioncare for patientscare of patientscare outcomescaring for patientscohortcommunity factorcommunity-level factordeprivationdevelopmentaldrinkingethanol consumptionethanol drinkingethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol ingestionethanol intakeethanol liver diseaseethanol product useethanol researchethanol useethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryethicalevidence baseexperiencefollow upfollow-upfollowed upfollowupgaps in accessgeographic sitehealth care outcomeshealth determinantshospital servicesimprovedimproved outcomeincomesindexinginterdisciplinary approachliver transplantationmethods to study multiple-level influencesmortalitymortality ratemortality ratiomulti-level analysismulti-level modelmultidisciplinary approachmultilevel analysismultilevel modelmultilevel modelingnewsparticipant enrollmentpatient enrollmentpatient oriented outcomespatient populationpatient subclasspatient subclusterpatient subgroupspatient subpopulationspatient subsetspatient subtypespilot studypost-transplantpost-transplantationposttransplantposttransplantationresolutionsresponsesobersobrietysocial mediasocio-demographic factorssociodemographic factorssubstance use and disordertransplanttransplant centerstransplant patientwaitlist
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In 2021, Alcoholic Liver Disease (ALD) accounted for 37% of liver transplants (LTs) performed in the United States. Given concerns for relapse in alcohol use post-transplant, most centers require that candidates have been abstinent from alcohol use for 6-months prior to being placed on the waitlist for transplant. However, a subset of patients…
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