grant
Multidimensional predictive modeling to understand mechanisms of exercise response heterogeneity in older adults
Organization FLORIDA INSTITU /HUMAN/MACHINE COGNITIONLocation PENSACOLA, UNITED STATESPosted 15 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY202521+ years oldAcuteAddressAdjuvantAdultAdult HumanAgingBehaviorBiogenesisBiologicalBiological FunctionBiological ProcessBloodBlood Reticuloendothelial SystemBody TissuesCell Communication and SignalingCell SignalingCircadian DysregulationClassificationClinicalCollectionCommunicationContinuous Glucose MonitorCoupledDeteriorationDietDimensionsDoseDrugsEducational workshopEndogenous FactorsExerciseExogenous FactorsFosteringGoalsGuidelinesHealth BenefitHeterogeneityImpairmentIndividualInflammationInfluentialsIntracellular Communication and SignalingKnowledgeLife StyleLifestyleLinkMedicationMetabolicMitochondriaModelingMolecularMuscleMuscle MitochondriaMuscle TissueNutritionOrigin of LifeOutcomeOutputParticipantPerformancePharmaceutical PreparationsPhasePhenotypePsyche structurePublic HealthQOLQuality of lifeRandomizedRecommendationResearch ResourcesResourcesRoleSarcosomesSequential Multiple Assignment Randomized TrialSeriesSignal TransductionSignal Transduction SystemsSignalingSleepSourceSpecific qualifier valueSpecifiedSystemSystematicsTestingTimeTissuesTitrationsTrainingVO2 maxVO2maxVariantVariationWorkshopadulthoodage associated functional declineage dependent functional declineage groupage induced loss of functionage related functional declineage-related loss of functionaging associated functional declineaging induced functional declineaging related functional declinebiologicbiological signal transductioncardiorespiratory fitnesscardiorespiratory healthcellular targetingcircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakerclinical phenotypecomputer based predictioncontinuous blood glucose monitorcontinuous blood sugar monitorcontinuous glucose measurementcontinuous sugar monitordesigndesigningdetermine efficacydietsdrug/agentefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy testingepigenomicsevaluate efficacyexamine efficacyexercise modalitiesexercise programexercise trainingextracellular vesiclesfitness programforgingfunctional decline due to agingfunctional decline with agefunctional decline with agingfunctional loss with aginghallmarks of aginghealthspanhealthy life spanimprovedindividual responseindividualized responseinnovateinnovationinnovativemachine learning based frameworkmachine learning frameworkmaximal oxygen uptakementalmitochondrialmode of exercisemultipotencymultipotentmuscle bulkmuscle formmuscle massmuscularolder adultolder adulthoodphase 1 trialphase 2 trialphase I trialphase II trialpillars of agingpredictive modelingprotein homeostasisproteostasisrandomisationrandomizationrandomly assignedresistance exerciseresistance trainingresponsesexsocial roletranscriptomics
Description preview
Aging-related functional declines are thought to be caused by hallmark biological processes that ultimately
compromise healthspan and quality of life (QoL). Exercise is a multipotent treatment with promise to mitigate
most aging hallmarks, but there is substantial variability in individual exercise responsiveness. This inter-
individual response…
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