grant
Multicenter Study of Microbial Profiles for Management of Hepatic Encephalopathy in Veterans with Cirrhosis
Organization VA VETERANS ADMINISTRATION HOSPITALLocation RICHMOND, UNITED STATESPosted 1 Apr 2026Deadline 31 Mar 2030
VANIHUS FederalResearch GrantFY20264-O-beta-D-galactopyranosyl-D-fructoseActive Follow-upAffective DisordersAmentiaCaringCephulacChronulacCirrhosisClinicClinicalCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCollectionCommunicationDataDementiaDiagnosisDiagnostic testsDifferential DiagnosisDiseaseDisorderDisturbance in cognitionDrugsEnrollmentEpidemicEvaluationExclusionFamily memberFecesFunctional MetagenomicsHepatic CirrhosisHepatic EncephalopathyHepatocerebral EncephalopathyImpaired cognitionImpairmentInterviewInvestmentsLactuloseLiver CirrhosisMachine LearningMeasuresMedicationMetagenomicsMicrobeMood DisordersMulti-center studiesMulticenter StudiesNeuropsychologic TestsNeuropsychological TestsNeuropsychologiesNeuropsychologyNewly DiagnosedObstructive Sleep ApneaOut-patientsOutcomeOutpatientsPTSDParalysis AgitansParkinsonParkinson DiseasePatient EducationPatient InstructionPatient Outcomes AssessmentsPatient Reported MeasuresPatient Reported OutcomesPatient TrainingPatientsPharmaceutical PreparationsPortal-Systemic EncephalopathyPortosystemic EncephalopathyPost-Traumatic NeurosesPost-Traumatic Stress DisordersPosttraumatic NeurosesPrimary ParkinsonismProspective StudiesProviderPublicationsReproducibilityResearchScientific PublicationSiteSpecialtySpecificityStandardizationSubstance abuse problemSymptomsSyndrome, Sleep Apnea, ObstructiveTest ResultTestingTexasTimeTrainingTranslatingVeteransWorkabuse of substancesactive followupaddictionaddictive disordercirrhoticclinical careclinical decision-makingclinical diagnosisclinical practiceclinical predictorsclinical relevanceclinically relevantco-morbidco-morbiditycognitive assessmentcognitive dysfunctioncognitive losscognitive testingcohortcomorbiditydrug/agentenrollfecal microbiomefecal samplefollow upfollow-upfollowed upfollowupgut to brain axisgut-brain axisgut-brain communicationgut-brain interactionsgut-brain relationshipgut-brain signalinghepatic coma/encephalopathyimprovedimproved outcomemachine based learningmachine learning based methodmachine learning methodmachine learning methodologiesmedical specialtiesmental functionmicrobialmicrobiomemicrobiome community compositionmicrobiome compositionmicrobiome species compositionmicrobiome structuremild cognitive declinemild cognitive disordermild cognitive dysfunctionmild cognitive impairmentmild cognitive lossmild neurocognitive impairmentnano porenanoporeneuropsychologicpost-trauma stress disorderposttrauma stress disorderprimary outcomeprospective research studyprospective surveypsychosocialresponserifaximinshared decision makingstoolstool microbiomestool samplestool specimenstool-associated microbiomesubstance abusetraumatic neurosis
Description preview
Cognitive impairment is epidemic in Veterans with cirrhosis, which poses a major psychosocial, financial, and
clinical burden. While it is assumed that hepatic encephalopathy (HE, both minimal, MHE or overt forms) is the
major cause of this impairment, recent work by our group has shown the frequent other causes/contributors in
up to half of…
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