grant
Multi-tissue type condensations for trachea tissue regeneration via individual cell bioprinting
Organization JESSE BROWN VA MEDICAL CENTERLocation CHICAGO, UNITED STATESPosted 1 May 2023Deadline 30 Apr 2028
VANIHUS FederalResearch GrantFY20253-D3-D print3-D printer3-Dimensional3D3D Print3D printer3D printingAblationAddressAffectAirway failureAnastomosisAnastomosis - actionAnimalsArmed Forces PersonnelAutologousBacterial InfectionsBathingBathsBenignBiochemicalBiocompatible MaterialsBiomaterialsBlood VesselsBody TissuesCancersCartilageCartilaginous TissueCell BodyCell CommunicationCell DensityCell FunctionCell Growth in NumberCell InteractionCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCell-Extracellular MatrixCell-to-Cell InteractionCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationCessation of lifeChondrogenesisComplexDeathDefectDevicesDomestic RabbitECMEngineeringEpithelial CellsEpitheliumExtracellular MatrixGelGelatinGeometryGrowth AgentsGrowth FactorGrowth SubstancesGunshot woundHistologicHistologicallyHistologyHumanImmune responseImplantIndividualInflammatory ResponseIntubationLaser ElectromagneticLaser RadiationLasersLifeMaintenanceMalignant NeoplasmsMalignant TumorManualsMechanicsMesenchymal Progenitor CellMesenchymal Stem CellsMesenchymal progenitorMesenchymal stromal/stem cellsMilitaryMilitary PersonnelModelingModern ManMucosaMucosal TissueMucous MembraneNutrientOrganOryctolagus cuniculusPainPainfulPatientsPenetrationPerformancePhenotypePhysical condensationPhysiologicPhysiologicalPolymersPrintingProductionProteins Growth FactorsQOLQuality of lifeRabbitsRabbits MammalsRadialRadiusResolutionRespiratory EpitheliumRespiratory FailureRoleSoldierSourceStentsStructureStructure of respiratory epitheliumSubcellular ProcessTechnologyTestingTherapeuticTissue DifferentiationTissue EngineeringTissue constructsTissuesTracheaTrachea ProperTracheal StenosisTracheostomyTracheostomy procedureTraumaTubeTubularTubular formationVascular SystemVascularizationVasculogenicVeteransWorkairway epitheliumbacteria infectionbacterial diseasebio-printingbioengineered tissuebioinkbiological materialbiomaterial scaffoldbiomechanical analysesbiomechanical analysisbiomechanical assessmentbiomechanical characterizationbiomechanical evaluationbiomechanical measurementbiomechanical profilingbiomechanical testbioprintingbioscaffoldbronchial epitheliumcartilaginouscell typeclinical relevanceclinically relevantcombatcondensationcrosslinkdesigndesigningdisabilityeffective therapyeffective treatmentendothelial progenitorendothelial progenitor cellendothelial stem cellengineered tissueflexibilityflexiblegunshot injuryhealinghost responseimmune system responseimmunoresponsein vivomalignancymanufacturemechanicmechanicalmechanical propertiesmesenchymal stromal cellmesenchymal stromal progenitor cellsmesenchymal-derived stem cellsmilitary populationmilitary veteranneoplasm/cancerparticlephysical propertypolymerpolymericpreventpreventingregenerate new tissueregenerate tissueregenerating damaged tissueregenerating tissueresolutionsrespiratoryrespiratory tract epitheliumrestenosisscaffoldscaffoldingself assemblysocial rolethree dimensionalthree dimensional printingtissue regenerationtissue regrowthtissue renewaltissue specific regenerationvascularveteran populationwindpipe
Description preview
Abstract
As a result of prolonged intubation, tracheostomy, external trauma, penetrating fragment projectiles, gunshot
wounds and improvised explosive devices during combat, and benign or malignant tumors, many soldiers and
veterans in the US military suffer from severe trachea stenosis or damage that can cause complete airway failure,
Since there…
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