grant
Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power Output
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 15 Jun 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025ATP HydrolysisAccountingAgeAnatomic SitesAnatomic structuresAnatomyAnimal ModelAnimal Models and Related StudiesArteriesArtificial HeartBaroreceptor ReflexBaroreflexBiochemicalBlood VesselsCardiacCardiac Muscle CellsCardiac MyocytesCardiac OutputCardiocyteCardiopulmonaryCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular PhysiologyCardiovascular systemComputer ModelsComputerized ModelsCouplingDataData SetDiastolic heart failureDysfunctionEFRACEjection FractionEnergy ExpenditureEnergy MetabolismEnergy SupplyEquilibriumExerciseExercise TestFailureForce of GravityFree EnergyFunctional disorderGoalsGravitiesHF with preserved ejection fractionHFpEFHeartHeart Muscle CellsHeart VascularHeart failureHeart myocyteHumanHydrolysisImageImpairmentIndividualIntermediary MetabolismIntrinsic factorLeftLegLinkMR ImagingMR SpectroscopyMR TomographyMRIMRIsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMechanicsMediatingMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic ProcessesMetabolic dysfunctionMetabolismModelingModern ManMonitorMuscleMuscle TissueMyocardialMyocardiumNMR ImagingNMR TomographyNuclear Magnetic Resonance ImagingO elementO2 elementOutputOxygenPatientsPerformancePeripheralPhenotypePhosphatesPhysiologicPhysiologicalPhysiologyPhysiopathologyPosturePower SourcesPower SuppliesPumpQOLQuality of lifeRelaxationResearchRestStressSystemSystems AnalysesSystems AnalysisTestingVasodilatationVasodilationVasorelaxationVenous Blood PressureVenous PressureVenous Pressure levelVentricularWorkZeugmatographyagedagesautonomic reflexbalancebalance functioncardiac MRIcardiac failurecardiac functioncardiac magnetic resonance imagingcardiac musclecardiac prosthesiscardiomyocytecardiorespiratory fitnesscardiorespiratory healthcardiovascular disordercardiovascular functioncirculatory systemclinical phenotypecohortcomputational modelingcomputational modelscomputer based modelscomputerized modelingexercise capacityexercise intolerancefunction of the hearthealthy aginghealthy human agingheart failure with preserved ejection fractionheart failure with preserved systolic functionheart functionheart muscleheart outputheart prosthesishemodynamicshuman datahuman modelhuman subjectimagingimpaired capacityin vivoinorganic phosphatemechanicmechanicalmechanical heartmodel of animalmodel of humanmortalitymulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingmuscularpathophysiologypreservationpreserved ejection fraction heart failureprosthetic heartrecruitresponsesexsimulationstudy populationvascularvascular constrictionvasoconstriction
Description preview
Title:
Multi-Scale Systems Analysis of Metabolic and Mechanical Determinants of Reserve Cardiac Power
Output
Abstract:
Exercise capacity, a central factor in determining quality of life in healthy aging as well as
cardiovascular disease, is determined by a systems-level interaction of factors that are intrinsic to the
heart and myocardium and…
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