grant
Multi-Omics Approaches for the Diagnosis and Risk Stratification of Pulmonary Fibrosis-Associated Pulmonary Hypertension
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Aug 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025BNP Gene ProductBNP-32Biological MarkersBiometricsBiometryBiostatisticsBloodBlood GroupingBlood Reticuloendothelial SystemBlood SampleBlood TypingBlood specimenBlood typing procedureBone Morphogenetic Protein GeneBone Morphogenetic ProteinsBrain Natriuretic Peptide-32Brain natriuretic peptideCaliforniaCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCell BodyCellsChronic lung diseaseClinicalClinical DataClinical MarkersClinical ResearchClinical StudyClinical TrialsCoupledCritical CareDataData AnalysesData AnalysisData SetDetectionDevelopmentDiagnosisDiseaseDisease MarkerDisease ProgressionDisorderDysfunctionEarly DiagnosisEarly treatmentEchocardiogramEchocardiographyEpidemiologyEpitheliumEvaluationExhibitsFibrosing AlveolitisFibrotic lesions in lungFoundationsFunctional disorderFutureGene ExpressionGene TranscriptionGenesGenetic TranscriptionGoalsHigh PrevalenceHumanInstitutionInvestigatorsK-AwardsK-Series Research Career ProgramsK23 AwardK23 MechanismK23 ProgramLab FindingsLaboratory FindingLos AngelesLungLung DiseasesLung GraftingLung ParenchymaLung Respiratory SystemLung TissueLung Tissue FibrosisLung TransplantationLung scarLung tissue scarMachine LearningMentored Patient-Oriented Research Career Development AwardMentored Patient-Oriented Research Career Development Award (K23)MentorsMesenchymalMethodsMicro Array DataMicroarray AnalysisMicroarray-Based AnalysisModern ManMorbidityMorbidity - disease rateMyocardial depressionMyocardial dysfunctionNatriuretic Factor-32NesiritideNewly DiagnosedNuclear RNAOutcomePathogenesisPathogenicityPathologyPathway interactionsPatientsPeripheralPhysiciansPhysiopathologyProbabilistic ModelsProbability ModelsProcessPulmonary DiseasesPulmonary DisorderPulmonary FibrosisPulmonary GraftPulmonary HypertensionPulmonary ScarPulmonary Tissue fibrosisPulmonary TransplantPulmonary TransplantationPulmonary Vascular ResistanceRNA ExpressionRNA SeqRNA sequencingRNAseqRegistriesResearchResearch Career ProgramResearch DesignResearch PersonnelResearchersRiskRisk ManagementScarring at the lungScarring in the lungSeverity of illnessSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSingle-Nucleus SequencingStandardizationStatistical ModelsStructure of parenchyma of lungStudy TypeTimeTranscriptionTranslational ResearchTranslational ScienceTransplantationTransthoracic EchocardiographyType-B Natriuretic PeptideUniversitiesVascular DiseasesVascular DisorderVascular remodelingWhole BloodWorkY Chromosomebio-markersbiobankbiologic markerbiomarkerbiomarker identificationbiorepositoryblood groupblood vessel disorderblood-based biomarkerblood-based markerbone lossbone morphogenic proteinbrain Natriuretic factorcardiac dysfunctionchronic pulmonary diseaseclinical biomarkersclinical riskclinical significanceclinically significantclinically useful biomarkerscohortcompare to controlcomparison controldata interpretationdevelopmentaldiffuse interstitial pulmonary fibrosisdisease of the lungdisease severitydisorder of the lungearly detectionearly therapyepidemiologicepidemiologicalfibrosis in the lungfibrotic lungglobal gene expressionglobal transcription profileheart dysfunctionheart sonographyhemodynamicsidentification of biomarkersidentification of new biomarkersidiopathic pulmonary fibrosisimpaired pulmonary vascularizationimprovedinsightlung disorderlung fibrosislung transplantlung vascular diseaselung vascular remodelingmachine based learningmarker identificationmicroarray analysesmicroarray technologymortalitymultidisciplinarymultiomicsmultiple omicsnew drug targetnew drug treatmentsnew druggable targetnew drugsnew markernew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovelnovel biomarkernovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel markernovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetobservational cohort studypanomicspathophysiologypathwaypatient oriented researchpatient oriented studyperipheral bloodpredictive biological markerpredictive biomarkerspredictive markerpredictive molecular biomarkerpreventpreventingprogramsprospectivepulmonarypulmonary arterial hypertensionpulmonary artery hypertensionpulmonary vascular diseasepulmonary vascular disorderpulmonary vascular dysfunctionpulmonary vascular remodelingpulmonary vasculopathyright heart failureright sided heart failureright ventricle failureright ventricular failureright ventricular heart failurerisk stratificationsNuc-Seqscreeningscreeningssingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqspecific biomarkersstatistical linear mixed modelsstatistical linear modelsstratify riskstudy designtherapeutic biomarkertherapeutic markertranscriptometranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation researchtranslational investigationtranslational investigatortranslational researchertranslational scientisttranslational studytransplantvalidation studiesvascular dysfunctionvasculopathy
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Project Summary
This is an application for a K23 award for Adam J Brownstein, MD, MS, a Pulmonary and Critical Care
physician at the University of California, Los Angeles. The goal of this proposal is for Dr. Brownstein to
establish himself as independent investigator in patient-oriented research in the field of pulmonary
hypertension, with a…
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