grant
Multi-Omics Analysis of Broadly Neutralizing Antibodies and Therapeutic Vaccination
Organization BETH ISRAEL DEACONESS MEDICAL CENTERLocation BOSTON, UNITED STATESPosted 11 Jul 2023Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026AssayBasic ResearchBasic ScienceBioassayBiologicalBiological AssayBody TissuesCell Mediated ImmunologyCell-Mediated ImmunityCellular ImmunityComputer AnalysisData SetDevelopmentGoalsHIV cureHIV functional cureHIV-1HIV-1 cureHIV-1 functional cureHIV-1 vaccineHIV-IHIV/AIDS cureHIV1HIV1 vaccineHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency Virus-1Human immunodeficiency virus 1ImmuneImmune responseImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsIntervention StudiesLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic nodesLymphoid TissueMediatingModern ManMucosaMucosal TissueMucous MembraneP01 MechanismP01 ProgramPathway interactionsPeripheralProgram Project GrantProgram Research Project GrantsResearchResearch Program ProjectsSHIVSIVSampling StudiesSimian Immunodeficiency VirusesTestingTissuesTreatment EfficacyVAC-TXVaccine TherapyVaccinesViralViral reservoirVirus reservoiranimal resourceanti-viral efficacyanti-viral immunityantiretroviral therapyantiretroviral treatmentantiviral immunitybiologicchallenge in rhesus macaquescombinatorialcomputational analysescomputational analysiscomputer analysesdata integrationdevelopmentalgastrointestinalhost responsehuman immunodeficiency virus cureimmune system responseimmunization strategyimmunoresponseimprovedinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesintervention efficacyintervention researchinterventional researchinterventional studyinterventions researchlymph glandlymph nodeslymphnodesmultiomicsmultiple omicsneutralizing antibodynext generationnon-human primatenonhuman primatepanomicspathwayprogramsrhesus challengerhesus macaque challengerhesus monkey infectionsimian HIVsimian human immunodeficiency virusspatial multiomicsspatial omicsspatial tri-omicstherapeutic efficacytherapeutic vaccinationtherapeutic vaccinetherapy efficacytreatment vaccinesvaccination strategyvaccine against HIV-1vaccine efficacyvaccine for the treatmentvaccine for treatmentviral reboundvirus rebound
Description preview
SUMMARY
The goal of this P01 program is to define mechanisms of efficacy of broadly neutralizing antibodies (bNAbs) and
therapeutic vaccines for HIV-1 in a highly collaborative and multifaceted research program. Our overall
hypothesis is that immunologic strategies for HIV-1 cure delay viral rebound both by targeting the viral
reservoir and by…
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