grant
Multi-modal profiling of spatially resolved cell types mediating opioid withdrawal
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 30 Sept 2023Deadline 31 May 2028
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DATAC sequencingATAC-seqATACseqAbstinenceAffectiveAnatomic SitesAnatomic structuresAnatomyAnimalsAssay for Transposase-Accessible Chromatin using sequencingAtlasesBehavioralBiologicalBrainBrain Nervous SystemBrain regionCell BodyCell NucleusCellsChemical DependenceChromatinChromatin StructureChronicComplexCuesDataDrug AddictionDrug DependenceDrug DependencyDrug usageDrugsEncephalonEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExposure toExpression SignatureGene Action RegulationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfileGene Expression ProfilingGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionImageImaging technologyLabelLearningLong-Term PotentiationMaintenanceMediatingMedicationMemoryMethodsMiceMice MammalsModificationMolecularMolecular TargetMurineMusNegative ReinforcerNerve CellsNerve UnitNeural CellNeural TransmissionNeurobiologyNeurocyteNeuronsNucleusNucleus AccumbensOpiate AddictionOpiate DependenceOpiate userOpiatesOpioidOpioid AnalgesicsOpioid drug userPWUOParaventricular Nucleus of ThalamusParaventricular Thalamic NucleusPathway interactionsPharmaceutical PreparationsPhysiologicPhysiologicalRNA ExpressionRecommendationRegulatory ElementRelapseResolutionRetrievalRoleSamplingSingle cell seqSingle-Nucleus SequencingSleepSpatial DistributionStructureStructure of paraventricular nucleus of thalamusSubgroupSymptomsSynapsesSynapticSynaptic TransmissionTextTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionUnited StatesVisualizationWithdrawalWithdrawal SymptomWorkaddictionaddictive disorderanalyze gene expressionassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingbasebasesbiologiccell typedrug cravingdrug relapsedrug seeking behaviordrug usedrug/agentepigeneticallyepigenomicsexperimentexperimental researchexperimental studyexperimentsfeedingfightinggene expression analysisgene expression assaygene expression patterngene expression signaturegene manipulationgenetic manipulationgenetically manipulategenetically perturbglobal gene expressionglobal transcription profileimagingknock-downknockdownmotivated behaviormulti-modalitymultimodalitymultiomicsmultiple omicsnegative affectnegative affectivityneural networkneurobiologicalneuronalneuronal circuitneuronal circuitrynew approachesnovelnovel approachesnovel strategiesnovel strategyopiate analgesiaopiate analgesicopiate consumptionopiate crisisopiate deathsopiate drug useopiate exposureopiate intakeopiate mortalityopiate pain medicationopiate pain relieveropiate useopiate withdrawalopioid addictionopioid analgesiaopioid anestheticopioid consumptionopioid crisisopioid deathsopioid dependenceopioid dependentopioid detoxopioid detoxificationopioid drug useopioid epidemicopioid exposureopioid intakeopioid medication abuseopioid mortalityopioid overdose deathopioid pain medicationopioid pain relieveropioid painkilleropioid prescription drug abuseopioid related deathopioid useopioid useropioid withdrawalpanomicspathwaypeople who use opioidspersons who use opioidsprescription opiate abuseprescription opioid abuseprevent relapsepromoterpromotorpsychological symptomrelapse preventionresolutionsresponsesNuc-SeqscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell analysissingle cell expression profilingsingle cell next generation sequencingsingle cell sequencingsingle cell transcriptomic profilingsingle nucleus RNA-sequencingsingle nucleus seqsingle-cell RNA sequencingsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesynapsethree dimensionaltranscriptional profiletranscriptional profilingtranscriptional signaturetranscriptometranscriptomics
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Opioid addiction is now the fastest growing drug problem in the United States. Chronic opioid use induces opioid dependence, which is characterized by extremely unpleasant physiological and psychological symptoms…
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