grant

Multi-Level Risk of Polysubstance use Trajectory and Leveraging Machine Learning Approaches to Detect Overdose Risk

Organization COLUMBIA UNIVERSITY HEALTH SCIENCESLocation NEW YORK, UNITED STATESPosted 1 Sept 2025Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldAdd HealthAddressAdolescentAdolescent YouthAdultAdult HumanAgeApplications GrantsAreaAwardBayesian AnalysisBayesian ModelingBayesian adaptive designsBayesian adaptive modelsBayesian belief networkBayesian belief updating modelBayesian computationBayesian frameworkBayesian hierarchical modelBayesian inferenceBayesian network analysisBayesian network modelBayesian nonparametric modelsBayesian spatial analysisBayesian spatial data modelBayesian spatial image modelsBayesian spatial modelsBayesian statistical analysisBayesian statistical inferenceBayesian statistical modelsBayesian statisticsBayesian tracking algorithmsBehavioralBenzodiazepine CompoundsBenzodiazepinesBiometricsBiometryBiostatisticsCocaineCrystal MethCrystal methamphetamineDataData ScienceData SetData SourcesDeoxyephedrineDesoxyephedrineDevelopmentDevelopment PlansDistalDrug CombinationsDrug userDrugsEducational workshopEnrollmentEnsureEnvironmentEpidemicEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiologyEpidemiology ResearchEquationEthnic OriginEthnicityEventFatal OutcomeFosteringGenderGoalsGrant ProposalsHealthHealth Care ProfessionalHealth ProfessionalIndividualInterventionInvestigatorsJointsK01 AwardK01 MechanismK01 ProgramLife ExpectancyLongitudinal StudiesMachine LearningMedicationMentored Research Scientist Development AwardMentored Training AwardMentorsMentorshipMethamphetamineMethodologyMethodsMethylamphetamineModelingMotivationMovementMusciN-MethylamphetamineNIDANaloxoneNarcanNarcantiNational Institute of Drug AbuseNational Institute on Drug AbuseNational Longitudinal Study of Adolescent HealthNational Longitudinal Survey of Adolescent to Adult HealthObservation researchObservation studyObservational StudyObservational researchOpiatesOpioidOutcomeOverdoseOverdose reversalPWUDParticipantPatternPersonsPharmaceutical PreparationsPredicting RiskPreventative strategyPrevention strategyPreventive strategyProceduresPublic HealthRaceRacesResearchResearch PersonnelResearch Scientist Development AwardResearchersRiskRisk AssessmentRoleSamplingScientistStimulantStrategic PlanningSurvival AnalysesSurvival AnalysisTechniquesTestingTimeTime FactorsTrainingTraining ProgramsTypologyUnited StatesWorkWorkshopadulthoodadverse consequenceadverse outcomeagesbody movementcareercareer developmentcausal diagramcausal modelclass Muscicomputer based predictionconferenceconventiondeprivationdevelopmentaldrug/agentenrollepidemiologicepidemiologic investigationepidemiologicalepidemiology studyexperienceexposure to violenceforecasting riskhigh riskinnovateinnovationinnovativeinsightinvestigator trainingjuvenilejuvenile humanlong-term studylongitudinal outcome studiesmachine based learningmachine learned algorithmmachine learning algorithmmachine learning based algorithmmachine learning based prediction modelmachine learning based predictive modelmachine learning predictionmachine learning prediction modelmarkov modelmethmortalitymultidisciplinarymultiple substance usemultisubstance usenovelopiate crisisopiate overdoseopiate related overdoseopioid crisisopioid drug overdoseopioid epidemicopioid induced overdoseopioid intoxicationopioid medication overdoseopioid overdoseopioid poisoningopioid related overdoseopioid toxicityoverdose deathoverdose fatalitiesoverdose preventionoverdose riskpeople who use drugspeople who use illicit drugspersons who use drugspoly substance usepolysubstance usepredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive modelingpredictive riskpredicts riskprevent substance useprevention effectivenesspsychosocialpsychostimulantpublic health interventionracialracial backgroundracial originresponsereverse overdoserisk predictionrisk prediction algorithmrisk prediction modelrisk predictionsskillssocial rolestructural determinantsstructural factorssubstance misusesubstance usesubstance use preventionsubstance usingsummitsymposiasymposiumtreatment strategytrendusabilityviolence exposure
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PROJECT SUMMARY/ABSTRACT
Significance. Recent national drug-involved overdose death data has shown that the current opioid epidemic

is characterized by four salient waves that claimed over 106,000 lives in 2021 alone. The current fourth wave

of the epidemic is characterized as an opioid-stimulant polysubstance use. However, it is still unclear how…

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Multi-Level Risk of Polysubstance use Trajectory and Leveraging Machine Learning Approaches to Detect Overdose Risk — CO | Dev Procure