grant
mTOR signaling and regulation of alpha-cell mass and function
Organization MIAMI VA HEALTH CARE SYSTEMLocation MIAMI, UNITED STATESPosted 1 Jan 2016Deadline 31 Mar 2028
VANIHUS FederalResearch GrantFY20254E-BP1AcidsAdult-Onset Diabetes MellitusAffectAlpha CellAmino AcidsAnimal ExperimentsAntidiabetic HormoneB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBP2Beta CellBrittle Diabetes MellitusCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsChronicClinical DataComplexD-GlucoseDataDefectDextroseDiabetes MellitusDimethylbiguanidineDimethylguanylguanidineDiseaseDisorderDysfunctionEIF4EBP1EIF4EBP1 geneEquilibriumExhibitsEyeEyeballFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FRAP1FRAP1 geneFRAP2Functional disorderFundingGenerationsGeneticGenetic ModelsGlucagonGlucagon CellGlucagon ReceptorGlucagon Secreting CellGlucoseGlukagonGoalsHG-FactorHamartinHealthHumanHumulin RHyperglycemiaHyperglycemic-Glycogenolytic FactorHypoglycemiaIBP2IDDMIGF-BP53IGFBP2IGFBP2 geneIndividualInsulinInsulin CellInsulin ReceptorInsulin Receptor Protein-Tyrosine KinaseInsulin ResistanceInsulin Secreting CellInsulin-Dependent Diabetes MellitusInsulin-Dependent Tyrosine Protein KinaseInsulin-Like Growth Factor Binding Protein 2Intracellular Communication and SignalingIslands of Langerhans TransplantationIslands of Pancreas TransplantationIslets of Langerhans GraftingIslets of Langerhans TransplantationJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKnowledgeLiverMaturity-Onset Diabetes MellitusMechanistic Target of RapamycinMetforminMiceMice MammalsModelingModern ManMolecularMurineMusN,N-dimethyl-imidodicarbonimidic diamideNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNovolin RNutrientObesityOvernutritionPancreatic Islets TransplantationPathogenesisPathway interactionsPatientsPhysiologicPhysiologicalPhysiopathologyPlayPredispositionPublishingRAFT1RapamuneRapamycinReceptor SignalingRegular InsulinRegulationResearchRodent ModelRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSirolimusSlow-Onset Diabetes MellitusStable Diabetes MellitusStrains Cell LinesSudden-Onset Diabetes MellitusSusceptibilityT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTSC1TSC1 geneTSC2TSC2 geneTSC4TSC4 GeneTestingTimeTuberinType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesUncertaintyVeteransadiposityadult onset diabetesalpha-cellaminoacidanimal experimentantagonismantagonistanterior chamberautologous islet transplantationbalancebalance functionbiological signal transductionblood glucose regulationcorpulencecultured cell linedesigndesigningdiabetesdiabetes controldiabetes managementdiabetes mellitus controldiabetes mellitus managementdiabetes mellitus therapydiabetes therapydiabetic managementdiabetogenicdoubtdrug developmentexperimentexperimental animalexperimental animalsexperimental researchexperimental studyexperimentsglucose controlglucose homeostasisglucose metabolismglucose regulationhepatic body systemhepatic organ systemhuman modelhyperglucagonemiahyperglycemichypoglycemichypoglycemic episodesimprovedin vivoinsightinsulin dependent diabetesinsulin dependent type 1insulin resistantinsulin secretioninsulin sensitivityinsulin toleranceintervention designisletislet auto transplantationislet beta cell transplantationislet cell transplantislet cell transplantationislet transplantationjuvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabetesmTORmammalian target of rapamycinmaturity onset diabetesmodel of humannew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypathophysiologypathwayphysiologic modelpreventpreventingreconstitutereconstitutionresponsesocial roletherapy designtreatment designtuberous sclerosis 1type 2 DMtype I diabetestype II DMtype one diabetestype two diabetesα-cellβ-cellβ-cellsβCell
Description preview
Diabetes mellitus is one of the most prevalent conditions affecting human health including veterans in the 21st
century. Most of the focus of our efforts to understand the pathogenesis and therapy of the disease has
focused on two major components: insulin sensitivity and insulin secretion. However, dysregulation in glucagon
secretion is a major…
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