grant

Molecular Transport of IFT Complexes in Leishmania

Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Nov 2025Deadline 31 Oct 2028
NIHUS FederalResearch GrantFY202520S Catalytic Proteasome20S Core Proteasome20S Proteasome20S ProteosomeAI systemActive Biologic TransportActive Biological TransportActive TransportAdaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneArchitectureArtificial IntelligenceBiologyCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCas nuclease technologyCell BodyCellsCessation of lifeCiliaClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColorComplexComputer ReasoningCryo-electron MicroscopyCryo-electron tomographyCryoelectron MicroscopyDNA mutationDeathDiseaseDisorderDrugsElectron CryomicroscopyEngineering / ArchitectureFlagellaFlagellataFluorescence Light MicroscopyFluorescence MicroscopyGene ModifiedGenetic ChangeGenetic EngineeringGenetic Engineering BiotechnologyGenetic Engineering Molecular BiologyGenetic defectGenetic mutationHairHumanIn SituIn VitroInfectionKnowledgeLeishmaniaLeishmaniasisLengthLinkMachine IntelligenceMacropainMacroxyproteinaseMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMastigophoraMediatingMedicationMicro-tubuleMicrotubulesModern ManMolecular TransportMotilityMotionMotorMulticatalytic ProteinaseMutationOrganellesParasitesPathogenesisPathogenicityPathway interactionsPharmaceutical PreparationsPolymersProsomeProteasomeProteasome Endopeptidase ComplexProtein translocationProteinsProteomeProteosomePublic HealthRecombinant DNA TechnologyResearchResolutionRibosomesRoleSiteStructureSwimmingSystemTherapeuticTrainingTransmembrane Protein TransportTransport ProcessUphill TransportVisualizationWorkadapter proteinbasebasescryo-EMcryo-EM tomographycryoEMcryoEM tomographycryoelectron tomographycryogenic electron microscopydrug/agentelectron cryo-tomographyflagellategene modificationgenetically engineeredgenetically modifiedgenome mutationimprovedin vivoinsightlive cell microscopymulticatalytic endopeptidase complexnovelparticlepathogenpathwaypolymerpolymericpolymerizationreconstitutereconstitutionresolutionsskillssocial roletherapeutic agent developmenttherapeutic developmenttrafficking
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Abstract/Summary:
Leishmania are obligate, intracellular parasites that are the causative agent of leishmaniasis—a disease

responsible for an estimated 1 million global infections each year, with ~70,000 fatalities. Therapeutics are

limited, and are generally restricted to general use, anti-protozoan drugs that lack efficacy, thus presenting…

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