grant
Molecular Studies of Cellular Cytotoxicity
Organization DIVISION OF BASIC SCIENCES - NCILocation UNITED STATES
NIHUS FederalResearch GrantFY2025Basal Transcription FactorBasal transcription factor genesBone Marrow GraftingBone Marrow TransplantBone Marrow TransplantationCancer TreatmentCell BodyCell DifferentiationCell Differentiation processCell Fate ControlCell Fate RegulationCell FunctionCell PhysiologyCell ProcessCell-Mediated CytolysisCell-Mediated LympholysisCellsCellular CytotoxicityCellular FunctionCellular PhysiologyCellular ProcessCenter for Cancer ResearchCytotoxic cellDevelopmentERYF1EXTMRElementsExtramuralExtramural ActivitiesFamilyGATA Binding Protein 1GATA-1GATA1GATA1 geneGATA1 proteinGATA1 transcription factorGEM geneGEM proteinGF-1 proteinGTP-Binding Mitogen-Induced T-Cell ProteinGene ExpressionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic DiversityGenetic PolymorphismGenetic VariationGoalsHLA-CHLA-C AntigensHematopoieticHistocompatibility ComplexHistocompatibility ComplicesHumanInnate Immune SystemInvestigationK lymphocyteKIR geneKIR proteinKinase-Inducible RAS-like ProteinLaboratoriesLigandsLymphocyte CytotoxicityLymphocytotoxicityMHC ReceptorMajor Histocompatibility ComplexMajor Histocompatibility Complex ReceptorMajor Histocompatibility ComplicesMalignant Neoplasm TherapyMalignant Neoplasm TreatmentMarrow TransplantationMiceMice MammalsModern ManMolecularMurineMusNCI Center for Cancer ResearchNF-E1 erythroid-specific transcription factorNFE1 proteinNK CellsNatural Killer CellsPopulationPublicationsReceptor CellReceptor ProteinRegulationResearchRoleScientific PublicationSubcellular ProcessT-Cell Antigen ReceptorsT-Cell ReceptorTranscription Factor GATA1Transcription Factor Proto-OncogeneTranscription factor genesUniversitiesVirusWashingtonWorkanti-cancer therapycancer therapycancer-directed therapycell mediated cytotoxicitycellular differentiationdevelopmentalglobin transcription factor 1hemopoieticnuclear factor-erythroid 1polymorphismprogramspromoterpromotorreceptorreceptor expressionsocial roletechnique developmenttranscription factortranscription factor NFE-1trophoblasttumor
Description preview
The overarching goal of this research program is the investigation of the innate immune system with a primary focus on natural killer (NK) cells and their use in the treatment of cancer. Our group has been a globally recognized leader in the study of the regulation of class I major histocompatibility complex (MHC) receptors in mouse (Ly49) and…
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