grant
Molecular regulation of stress sensing and processing in gram-positive and gram-negative bacterial models.
Organization OKLAHOMA STATE UNIVERSITY STILLWATERLocation STILLWATER, UNITED STATESPosted 15 Sept 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY2025AmericanAntibiotic TherapyAntibiotic TreatmentAntimicrobial ResistanceB subtilisB. subtilisBacillus subtilisBacteriaBacteria resistanceBacteria resistantBacterial ModelBacterial resistantBehaviorBindingCell BodyCell Communication and SignalingCell SignalingCell SurvivalCell ViabilityCellsCellular ExpansionCellular GrowthCellular injuryCommunicable DiseasesCuesEnvironmentEnvironmental PollutionEyeEyeballFluorescence Light MicroscopyFluorescence MicroscopyFutureGeneralized GrowthGoalsGrowthHealthHumanInfectionInfectious DiseasesInfectious DisorderIntracellular Communication and SignalingInvestigationLearningModelingModern ManMolecularMolecular InteractionNutrientNutritionalP aeruginosaP. aeruginosaPathway interactionsProcessProductionProteinsPseudomonas aeruginosaPseudomonas pyocyaneaRegulationRegulatory PathwayRegulatory ProteinResearchSensorySignal TransductionSignal Transduction SystemsSignalingStressSystemTechniquesTissue GrowthVirulenceanti-microbialanti-microbial resistantantimicrobialbacterial disease treatmentbacterial geneticsbacterial infectious disease treatmentbacterial resistancebiological adaptation to stressbiological signal transductionbiological systemscell damagecell growthcell injurycellular damagedamage to cellsenvironmental changeenvironmental contaminationfitnessgenetic regulatory proteinhuman pathogenimprovedinjury to cellsmicrobialmicrofluidic technologynutritiousontogenypathogenpathwayprogramsreaction; crisisregulatory gene productresistance to Bacteriaresistance to Bacterialresistance to anti-microbialresistant to Bacteriaresistant to Bacterialresistant to antimicrobialresponsesensory inputstress responsestress; reactionstressortreatment strategyµfluidic technology
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PROJECT SUMMARY
Bacteria use a remarkable array of responses to effectively survive and compete in ever-changing
environmental and internal conditions. To do so, they must sense environmental or internal cues and then
enact an appropriate response. Bacterial sensing impacts human health; for instance, stress-responding
bacteria can be recalcitrant…
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