grant
Molecular Regulation of Stem Cell Aging
Organization UNIVERSITY OF CALIFORNIA LOS ANGELESLocation LOS ANGELES, UNITED STATESPosted 1 Jul 2011Deadline 31 May 2029
NIHUS FederalResearch GrantFY2025AgeAgingAntibodiesAssayAtlasesBioassayBioinformaticsBiological AssayBody TissuesBone MarrowBone Marrow Reticuloendothelial SystemBrainBrain Nervous SystemCNS Nervous SystemCell BodyCell Communication and SignalingCell CycleCell Division CycleCell SignalingCellsCellular AssayCentral Nervous SystemChromatinComputing MethodologiesCytometryDataData CollectionDysfunctionElementsEncephalonEnsureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventFunctional disorderFundingGrantGraphHSC expansionHematopoieticImageImmuneImmunesInflammatoryIntermediary MetabolismIntracellular Communication and SignalingIsotopesLinkMapsMetabolicMetabolic ProcessesMetabolismMiceMice MammalsMolecularMultiplexed Ion Beam ImagingMurineMusMuscleMuscle TissueMyelogenousMyeloidNeighborhoodsNeural Stem CellNeuraxisOrganizational ChangePhenotypePhysiopathologyPlayProgenitor CellsPropertyProteomicsR-Series Research ProjectsR01 MechanismR01 ProgramRegulationRejuvenationReporterResearch GrantsResearch Project GrantsResearch ProjectsRoleSignal TransductionSignal Transduction SystemsSignalingSuspension substanceSuspensionsSystemTechniquesTechnologyTissue atlasTissue imagingTissuesTreesWorkage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesagesaging associatedaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging relatedaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with agebiological signal transductionblood progenitor cell expansionblood progenitor expansionblood stem cell expansioncell assaychanges with agechromatin modificationcomputational methodologycomputational methodscomputer based methodcomputer methodscomputing methoddensityepigeneticallyexperienceexperimentexperimental researchexperimental studyexperimentshematopoietic progenitor cell expansionhematopoietic progenitor expansionhematopoietic stem cell expansionhemopoieticimaginginnovative technologiesinventionmuscle progenitormuscle progenitor cellmuscle stem cellmuscularnano meter scalenano meter sizednanometer scalenanometer sizednanoscalenerve stem cellneural precursorneural precursor cellneural progenitorneural progenitor cellsneural stem and progenitor cellsneurogenic progenitorsneurogenic stem cellneuron progenitorsneuronal progenitorneuronal progenitor cellsneuronal stem cellsneuroprogenitornext generationnovelpathophysiologyprogenitor agingprogenitor and neural stem cellsprogenitor cell agingprogenitor cell poolprogenitor cell populationprogenitor poolprogenitor populationprogramssingle cell analysissocial rolestem and progenitor cell populationstem cell agingstem cell poolstem cell populationstem cellstissue/cell preparationtool
Description preview
SUMMARY
The Single Cell and Spatial Proteomics Core will provide access to highly multiplexed single
cell proteomic assays to reveal aging-related regulatory cell-states and their phenotypic identification and
localization. Based on innovative technologies pioneered in our lab, single cell mass cytometry (i.e.
CyTOF, for cell suspensions)1-2 and…
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