grant
Molecular Prosthetics and Lego Chemistry
Organization UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGNLocation CHAMPAIGN, UNITED STATESPosted 1 Jun 2016Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2026ASL deficiencyAnimalsAreaArgininosuccinate lyase deficiencyArgininosuccinic aciduriaArgininosuccinicaciduriaBiochemical ReactionBiologicalBiologyBloodBlood PlasmaBlood Reticuloendothelial SystemBody TissuesCapsulesChemicalsChemistryComplexCyclizationDevelopmentDiseaseDisorderEnzymatic ReactionEnzyme GeneEnzymesHealthHereditary TyrosinemiasHumanIndustrializationIon ChannelIonic ChannelsLaboratoriesLinkLipidsMedicineMembrane ChannelsMethodsModern ManMolecularNatural ProductsOrganic SynthesisOrganismOrnithine Carbamoyltransferase Deficiency DiseaseOrnithine Transcarbamylase Deficiency DiseaseOrnithine carbamoyltransferase deficiencyPersonsPhysiologyPlasmaPlasma SerumPolyunsaturated Fatty AcidsPredispositionPreparationProcessProsthesisProsthetic deviceProstheticsProtein DeficiencyReagentResearchReticuloendothelial System, Serum, PlasmaStructureSusceptibilityTerpene CompoundTerpenesTerpenoidsTissuesTyrosinemiasarginosuccinase deficiencybiologiccapsuledeficiency of proteindevelopmentalenzyme deficiencyflexibilityflexiblefrontierhuman diseasehyperammonemia due to ornithine transcarbamylase deficiencyhyperammonemic syndromeliving systemmimicrymolecular scalemouse modelmurine modelnaturally occurring productnew approachesnovel approachesnovel strategiesnovel strategyornithine transcarbamylase deficiencypreparationsprogramsrestorationself assemblysmall molecule
Description preview
Project Summary/Abstract
This proposal aims to substantially advance two frontier research areas, Molecular Prosthetics and Automated
Small Molecule Synthesis, and thereby have a major impact on human health. The first half targets the
development of a new class of molecular prosthetics that replace missing biochemical reactions. Our lab has…
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