grant
Molecular pathogenesis and therapy innovation for Merkel cell carcinoma
Organization NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASESLocation UNITED STATES
NIHUS FederalResearch GrantFY2025Aberrant ChromosomeAnimal ModelAnimal Models and Related StudiesBiological MarkersCancer CauseCancer EtiologyCancer cell lineCancersCarcinoma CellCell BodyCell Culture TechniquesCell LineCell TherapyCellLineCellsCharacteristicsChromosomal AberrationsChromosomal AbnormalitiesChromosomal AlterationsChromosome AberrationsChromosome AlterationsChromosome AnomaliesChromosome abnormalityClinical MarkersClinical ProtocolsCutaneous Neuroendocrine CarcinomaCytogenetic AberrationsCytogenetic AbnormalitiesDNA mutationDataDevelopmentDiagnosisDiagnosticDiseaseDisease ProgressionDisorderEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessGene AlterationGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene MutationGeneticGenetic ChangeGenetic defectGenetic mutationGenetic predisposing factorGoalsHeterograftHeterologous TransplantationHigh-Risk CancerHumanHuman Cell LineImmune responseIn VitroInfectionMalignantMalignant - descriptorMalignant Epithelial CellMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorMerkel Cell TumorMerkel CellsMerkel cell cancerMerkel cell carcinomaMerkel's ReceptorMiceMice MammalsModern ManModificationMolecularMurineMusMutationNeuroendocrine Carcinoma of the SkinNeuroendocrine CellOncogenicOutcomePathogenesisPathway interactionsPatientsPolyomaPolyoma VirusesPolyomavirusPolyomavirus Transforming AntigensPolyomavirus Tumor AntigensPopulationRiskSamplingSkinSkin CancerStrains Cell LinesT-CellsT-LymphocyteTestingTrabecular Skin CarcinomaTranscript Expression AnalysesTranscript Expression AnalysisTumor Cell LineValidationVirusWorkXenograftXenograft procedureXenotransplantationanalyze gene expressionbio-markersbiologic markerbiomarkercancer registrycell based interventioncell culturecell culturescell mediated interventioncell mediated therapiescell-based therapeuticcell-based therapycellular therapeuticcellular therapychromosomal defectchromosome defectclinical biomarkersclinically useful biomarkerscultured cell linedata registrydevelopmentalepigeneticallygene defectgene expression analysisgene expression assaygene manipulationgenetic manipulationgenetic risk factorgenetically manipulategenetically perturbgenome mutationgenome scalegenome-widegenomewidehost responseimmune system responseimmunogenicimmunoresponsein vivoinherited factorinnovateinnovationinnovativeknock-downknockdownmalignancymalignant skin tumormodel of animalmouse modelmurine modelmutant alleleneoplasm registryneoplasm/cancernovelpathwaypre-clinicalpre-clinical developmentpreclinicalpreclinical developmentpreventpreventingprognosticresponsesmall moleculetherapeutic targetthymus derived lymphocytetranscriptional profilingtumortumor growthvalidationsxeno-transplantxeno-transplantation
Description preview
To identify molecular drivers of Merkel cell carcinoma, we have conducted analyses of human tumors and cancer cell lines across multiple genome-wide platforms to assay gene expression, identify gene mutations, and characterize chromosomal alterations. These data are being analyzed to identify key driver alterations for this tumor. We are also…
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