grant
Molecular mechanisms that regulate vesicle formation and transport
Organization UNIVERSITY OF WISCONSIN-MADISONLocation MADISON, UNITED STATESPosted 1 Feb 2020Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025APF-1ATP-Dependent Proteolysis Factor 1AutoregulationBiochemistryBiogenesisBiologic ModelsBiological ChemistryBiological ModelsCancersCell DifferentiationCell Differentiation processCell Growth in NumberCell MultiplicationCell ProliferationCellular ProliferationCellular biologyComplexCytoplasmDNA mutationDefectDegenerative Neurologic DisordersDiabetes MellitusDiseaseDisorderEndoplasmic ReticulumEndosomesErgastoplasmEukaryotic CellFutureGeneticGenetic ChangeGenetic defectGenetic mutationGoalsGolgiGolgi ApparatusGolgi ComplexHMG-20High Mobility Protein 20HomeostasisImageImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmunologic DiseasesImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionInterventionIntracellular MembranesLaboratoriesLinkLipidsLocationLysosomesMalignant NeoplasmsMalignant TumorMammalian CellMediatingMembraneMembrane TransportMetabolic Protein DegradationMethodologyModel SystemMolecularMolecular Tumor SuppressionMovementMutationNerve DegenerationNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuron DegenerationOrganellesOrigin of LifePathway interactionsPhysiological HomeostasisPhysiological Subcellular TargetingPlayProcessProtein SortingsProtein TraffickingProtein TurnoverProteinsReceptor SignalingReceptosomesRegulationRegulatory Protein DegradationResearchResolutionSortingSubcellular Protein TargetingSystemTransmembrane TransportTumor SuppressionUbiquitinVesiclebody movementcell biologycellular differentiationdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdiabetesgenome mutationimaginginsightintracellular protein transportmalignancymembrane structureneoplasm/cancerneural degenerationneurodegenerationneurodegenerativeneurodegenerative illnessneurological degenerationneuronal degenerationpathwayprotein degradationprotein transportresolutionsstructural biologytherapeutic targettrafficking
Description preview
PROJECT SUMMARY
How the intracellular membrane system of eukaryotic cells is configured and maintained is a fundamental
problem in cell biology. Deficiencies in this organization often lead to disease. The overarching goal of my
laboratory is to define the molecular mechanisms that regulate membrane dynamics, including vesicle
biogenesis,…
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