grant
Molecular mechanisms regulating ciliary motility
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026AddressBiochemicalBiological FunctionBiological ProcessBiologyCell BodyCell Membrane ExtensionsCell Membrane ProjectionsCell Membrane ProtrusionsCell Surface ExtensionsCell Surface ProjectionsCell Surface ProtrusionsCell surfaceCellsChlamydomonas reinhardiiChlamydomonas reinhardtiiCiliaCollectionComplexCryo-electron MicroscopyCryoelectron MicroscopyCyclicityCytoplasmDyneinDynein ATPaseDynein Adenosine TriphosphataseDynein AdenosinetriphosphataseDysfunctionElectron CryomicroscopyEmbryo DevelopmentEmbryogenesisEmbryonic DevelopmentEukaryotic CellExhibitsFunctional disorderGeneticHumanIn SituInsect VectorsLeftMalariaMale InfertilityMicro-tubuleMicrotubulesModelingModern ManMolecularMolecular MachinesMotilityMotorMovementOrganellesPaludismParasitesPeriodicityPhysiopathologyPlasmodium InfectionsPlayProcessProteomicsRhythmicityRoleSightSpermSpermatozoaTrypanosomiasisVisionWorkbody movementchronic airway diseasechronic respiratory diseasecilium motilitycryo-EMcryoEMcryogenic electron microscopydevelop therapyimprovedinfertile malesinfertile meninfertility in meninsightinterdisciplinary approachintervention developmentmale factor infertilitymen facing infertilitymen with infertilitymodel organismmultidisciplinary approachparticlepathogenpathophysiologysocial rolesperm celltherapy developmenttreatment developmentvisual functionzoosperm
Description preview
Project Summary
The Brown lab seeks to understand molecular mechanisms of eukaryotic motile cilia, which are long, slender
cell surface projections that exhibit rhythmic beating. In humans, cilia play pivotal roles in many biological
processes, ranging from the self-propulsion of spermatozoa to the establishment of left-right asymmetry during…
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