grant
Molecular mechanisms of TAK1 regulation in rheumatoid arthritis
Organization WASHINGTON STATE UNIVERSITYLocation PULLMAN, UNITED STATESPosted 12 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025(TNF)-α3-10CAMCF-IATAC sequencingATAC-seqATACseqArthritogenicAssay for Transposase-Accessible Chromatin using sequencingAtrophic ArthritisB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor GeneB-Cell Differentiation Factor-2B-Cell Stimulatory Factor 2 GeneB-Cell Stimulatory Factor-2BCDFBSF-2BSF-2 GeneBSF2BSF2 GeneBeta Proprotein Interleukin 1Beta-2 Gene InterferonBody TissuesBone-Derived Transforming Growth FactorC-terminalCXCL1CXCL1 geneCXCL8CXCL9CXCL9 geneCachectinCartilageCartilaginous TissueCell BodyCell Communication and SignalingCell SignalingCellsChromatinCommon Rat StrainsDataDiseaseDisorderDoseE1A Binding Protein p300EP300EP300 geneFibroblastsGCP1GRO1GROAGene TranscriptionGenesGenetic TranscriptionHPGFHSF GeneHepatocyte Stimulatory Factor GeneHepatocyte-Stimulating FactorHistone AcetylaseHistone AcetylationHistone H3HumanHumigHybridoma Growth FactorHybridoma Growth Factor GeneHyperplasiaHyperplasticIFN-GammaIFN-beta 2IFN-gIFN-γIFNB2IFNB2 GeneIFNGIFNγIL-1 betaIL-1 βIL-1-bIL-1βIL-6IL-6 GeneIL-8IL1-BetaIL1-βIL1B ProteinIL1F2IL1βIL6IL6 ProteinIL6 geneIL8IL8 geneIPO-BImmuneImmune InterferonImmune PrecipitationImmunesImmunoblottingImmunoprecipitationIn VitroIncidenceIndophenol Oxidase BInflammationInflammatoryInterferon GammaInterferon Type IIInterleukin 1betaInterleukin 6 (Interferon, Beta 2) GeneInterleukin-1 betaInterleukin-1βInterleukin-6Interleukin-6 GeneInterstitial CollagenaseIntracellular Communication and SignalingInvadedJUN B Proto-oncogeneJUNBJUNB geneK60KAT3BKinasesLC/MSLinkLiquid ChromatographyMAP kinaseMAP kinase kinase kinase 7MAP3K7MAP3K7 geneMGI-2MGSAMIG GeneMMP-1MMP-1Fibroblast CollagenaseMMP-3MMP1MMP3MMP3 geneMNSODMacrophage-Derived TNFManganese Superoxide DismutaseMatrix Metalloproteinase 3Matrix Metalloproteinase-1MediatingMediatorMethodsMiceMice MammalsMilk Growth FactorMitochondrial Superoxide DismutaseMitogen-Activated Protein KinasesMn Superoxide DismutaseMn-SODModelingModern ManMolecularMonocyte-Derived TNFMurineMusMyeloid Differentiation-Inducing ProteinNuclearNuclear TranslocationOnset of illnessP/CAFPCAFPCAF genePathogenesisPathologicPathway interactionsPatientsPhenotypePhosphotransferase GenePhosphotransferasesPhysiologicPhysiologicalPlasmacytoma Growth FactorPlatelet Transforming Growth FactorPositionPositioning AttributePost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingPreinterleukin 1 BetaProductionProtein ModificationProteinsProteomicsRNA ExpressionRNA SeqRNA analysisRNA sequencingRNAseqRatRats MammalsRattusReceptor SignalingRegulationRepressionRheumatoid ArthritisRoleSCID MiceSCYB1SCYB8SCYB9SL-1SOD2SOD2 geneSTMYSTMY1STR1Severe Combined Immunodeficient MiceSeveritiesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinStromelysinStromelysin 1Superoxide Dismutase 2SynovitisTAK1TAK1aTAK1bTAK1cTAK1dTGF BTGF-Beta Activated Kinase 1TGF-betaTGF-beta-activated kinase 1TGF-βTGFbetaTGFβTLR proteinTNFTNF ATNF AlphaTNF geneTNF-αTNFATNFαTSG-1TestingTherapeuticTissuesToll-Like Receptor Family GeneToll-like receptorsTranscriptionTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneTransforming Growth Factor-Beta OverexpressionTransin-1TransphosphorylasesTumor Necrosis FactorTumor Necrosis Factor-alphaUbiquitilationUbiquitinationUbiquitinoylationWestern BlottingWestern ImmunoblottingWorkassay for transposase accessible chromatin followed by sequencingassay for transposase accessible chromatin seqassay for transposase accessible chromatin sequencingassay for transposase-accessible chromatin with sequencingb-ENAPbiological signal transductionbonechromatin remodelingchronic inflammatory diseasecollagen antibody induced arthritiscollagenase activating proteinconditional knock-outconditional knockoutcrg-10cytokinede-ubiquitinasede-ubiquitinating enzymedetermine efficacydisease onsetdisorder onsetefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacygain of functiongenome scalegenome-widegenomewidehistone acetyltransferasehistone acetyltransferase p300immunodeficient mouse modelin vivoinflamed synovial tissueinflamed synoviuminhibitorinterferon beta 2kinase inhibitorlFN-Gammaliquid chromatography mass spectrometryloss of functionmitogen-activated protein kinase kinase kinase 7noveloverexpressoverexpressionp300pathwayprocollagenase activatorprotein blottingproteoglycanaserecruitresponserestorationrheumatic arthritissocial rolesuccesssynovial inflammationtandem mass spectrometrytargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic targettranscriptome sequencingtranscriptomic sequencingtransforming growth factor-beta-activated kinase 1ubiquinationubiquitin conjugationubiquitin isopeptidaseubiquitin-specific isopeptidase
Description preview
PROJECT SUMMARY
In rheumatoid arthritis (RA), activated synovial fibroblasts (SFs) transform into an invasive phenotype that
recruits immune cells to cause tissue destruction. Recent findings show transforming growth factor β-activated
kinase 1 (TAK1) as a pivotal mediator of IL-1β, TNF-α, and Toll-like receptor signaling cascades due to its…
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