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Molecular mechanisms of sensing nuclear stress and launching antiviral defense by PML
Organization UNIVERSITY OF CONNECTICUT SCH OF MED/DNTLocation FARMINGTON, UNITED STATESPosted 1 Jun 2024Deadline 30 Apr 2026 ⚠️
NIHUS FederalResearch GrantFY2025AD dementiaAddressAffectAfferent NeuronsAffinityAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaAmino AcidsAnti-viral ResponseAssayBasic Mechanisms of SUMOylationBindingBioassayBiological AssayBiophysicsBlindnessBody SizeBrain InflammationC-terminalCancersCell BodyCellsCellular biologyCorneaDNADNA BindingDNA Binding DomainDNA Binding InteractionDNA DamageDNA InjuryDNA ReplicationDNA SynthesisDNA biosynthesisDNA boundDNA-Binding Protein MotifsDefectDegenerative Neurologic DisordersDeoxyribonucleic AcidDiseaseDisorderDisseminated SclerosisE3 LigaseE3 Ubiquitin LigaseEncephalitisEnzyme GeneEnzymesEventEvolutionFRETFamily memberFluorescenceFluorescence Light MicroscopyFluorescence MicroscopyFluorescence Resonance Energy TransferFörster Resonance Energy TransferGene ExpressionGeneralized GrowthGenesGeneticGenital OrgansGenitaliaGenomeGrowthHHV-2HHV2HSVHSV-1HSV-2HSV1HSV2Herpes SimplexHerpes Simplex InfectionsHerpes Simplex Type 1Herpes Simplex VirusHerpes Simplex Virus 1Herpes Simplex Virus 2Herpes Simplex Virus Type 1Herpes Simplex Virus Type 2Herpes labialis VirusHerpes simplex diseaseHerpesviridaeHerpesvirus 1Herpesvirus 2 (alpha), HumanHerpesvirus hominis diseaseHerpesvirus progenitalisHerpesvirusesHumanHuman (alpha) herpes virus 2Human Herpesvirus 2Human herpes simplex virus type 2IFNImmune responseIn VitroInducer of Promyelocytic Leukemia ProteinInfectionInterferonsIsoformsLabelLesionLifeLife CycleLife Cycle StagesLigaseLigase GeneMaintenanceMalignant NeoplasmsMalignant TumorMediatingModern ManMolecularMolecular InteractionMorbidityMorbidity - disease rateMultiple SclerosisN-terminalNH2-terminalNMR SpectrometerNMR SpectroscopyNervous System Degenerative DiseasesNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNuclearNuclear ProteinOralOxidative StressPML nuclear bodiesPeptide DomainPhasePhysical condensationPicoGreenPlaque AssayPlayPopulationPrimary Senile Degenerative DementiaProcessPromyelocytic Leukemia ProteinPropertyProtein DomainsProtein IsoformsProteinsRecurrent diseaseRelapsed DiseaseRoleSUMO ProteinsSUMOylationSensory NeuronsSentrin ProteinsSentrinsSeriesSimplexvirusSingle Crystal DiffractionSiteSmall Ubiquitin-Related Modifier ProteinsSpecificityStressStructureSumoylation PathwaySynthetasesTertiary Protein StructureTestingTissue GrowthTransfectionTripartite Motif Protein TRIM19Ubiquitin Protein LigaseUbiquitin-Protein Ligase ComplexesUbiquitin-Protein Ligase E3ViralViral DiseasesViral GenesViral GenomeVirusVirus DiseasesWorkX Ray CrystallographiesX-Ray CrystallographyX-Ray Diffraction CrystallographyX-Ray/Neutron CrystallographyXray Crystallographyacute infectionaminoacidarms racebiological adaptation to stressbiophysical foundationbiophysical principlesbiophysical sciencescell biologycondensationcongenital infectioncornealdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesherpes simplex iherpes simplex iiherpes simplex virus 1 infectionherpes simplex virus infectionherpes simplex-1herpes virushost responsehuman alphaherpesvirus 2human pathogenimmune system responseimmunoresponsein vitro activityinsightinsular sclerosisintermolecular interactionlatent persistent infectionlife coursemalignancymortalitymutantneoplasm/cancerneurodegenerative illnessnuclear magnetic resonance spectroscopynucleaseontogenyprimary degenerative dementiapromyelocytic leukemia nuclear bodiesprotein oligomerreaction; crisisrecruitresponsescaffoldscaffoldingsenile dementia of the Alzheimer typesensorsocial rolestress responsestress; reactiontranscription factor PMLubiquitin-protein ligaseviral DNAviral infectionvirus DNAvirus genomevirus infectionvirus-induced diseasevision lossvisual loss
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Description preview
ABSTRACT
The human herpesviruses are responsible for lifelong debilitating and congenital infections, and some members
of this family are associated with human cancers. HSV causes significant disease during acute infection and
establishes persistent latent infections in sensory neurons for the life of the host leading to reactivation and
recurrent…
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